Hydroxyethyl substituted linear polyethylenimine for safe and efficient delivery of siRNA therapeutics

Linear polyethylenimine (LPEI) has been well reported as a carrier for siRNA delivery. However, its applications are limited due to its highly ionized state at physiologic pH and the resultant charge mediated toxicity. The presence of ionizable secondary amines in LPE are responsible for its unique...

Descripción completa

Detalles Bibliográficos
Autores principales: Patil, Sushilkumar, Lalani, Rohan, Bhatt, Priyanka, Vhora, Imran, Patel, Vivek, Patel, Hinal, Misra, Ambikanandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087824/
https://www.ncbi.nlm.nih.gov/pubmed/35547911
http://dx.doi.org/10.1039/c8ra06298f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087824/
https://www.ncbi.nlm.nih.gov/pubmed/35547911
http://dx.doi.org/10.1039/c8ra06298f

Ejemplares similares