Cargando…

Hydroxyethyl substituted linear polyethylenimine for safe and efficient delivery of siRNA therapeutics

Linear polyethylenimine (LPEI) has been well reported as a carrier for siRNA delivery. However, its applications are limited due to its highly ionized state at physiologic pH and the resultant charge mediated toxicity. The presence of ionizable secondary amines in LPE are responsible for its unique...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patil, Sushilkumar, Lalani, Rohan, Bhatt, Priyanka, Vhora, Imran, Patel, Vivek, Patel, Hinal, Misra, Ambikanandan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087824/ https://www.ncbi.nlm.nih.gov/pubmed/35547911 http://dx.doi.org/10.1039/c8ra06298f

Ejemplares similares

Polyethylenimine-Conjugated Hydroxyethyl Cellulose for Doxorubicin/Bcl-2 siRNA Co-Delivery Systems
por: Park, Jiwon, et al.
Publicado: (2023)

Integration of Polylactide into Polyethylenimine Facilitates the Safe and Effective Intracellular siRNA Delivery
por: Ding, Guo-Bin, et al.
Publicado: (2020)

Effective Non-Viral Delivery of siRNA to Acute Myeloid Leukemia Cells with Lipid-Substituted Polyethylenimines
por: Landry, Breanne, et al.
Publicado: (2012)

Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines
por: Parmar, Manoj B., et al.
Publicado: (2015)

Targeting HPV‐infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine
por: Levine, Rachel M., et al.
Publicado: (2016)

Association of Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) and Thyroglobulin (TG) Genetic Variants with Autoimmune Hypothyroidism
por: Patel, Hinal, et al.
Publicado: (2016)

Cyclodextrin and Polyethylenimine Functionalized Mesoporous Silica Nanoparticles for Delivery of siRNA Cancer Therapeutics
por: Shen, Jianliang, et al.
Publicado: (2014)

Polymeric Nanoparticles Based on Tyrosine-Modified, Low Molecular Weight Polyethylenimines for siRNA Delivery
por: Ewe, Alexander, et al.
Publicado: (2019)

Enhanced Gene Silencing through Human Serum Albumin-Mediated Delivery of Polyethylenimine-siRNA Polyplexes
por: Nicolì, Elena, et al.
Publicado: (2015)

Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine
por: Xie, Yuran, et al.
Publicado: (2016)

Branched polyethylenimine-grafted-carboxymethyl chitosan copolymer enhances the delivery of pDNA or siRNA in vitro and in vivo
por: Park, Seong-Cheol, et al.
Publicado: (2013)

Superparamagnetic iron oxide nanoparticles modified with polyethylenimine and galactose for siRNA targeted delivery in hepatocellular carcinoma therapy
por: Yang, Zhen, et al.
Publicado: (2018)

Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease
por: Helmschrodt, Christin, et al.
Publicado: (2017)

Inhibition of Tumor Growth via Systemic siRNA Delivery Using Reducible Bile Acid-Conjugated Polyethylenimine
por: Yin, Yue, et al.
Publicado: (2018)

Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown
por: Noske, Sandra, et al.
Publicado: (2020)

cRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy
por: Yang, Shuang, et al.
Publicado: (2021)

Low-weight polyethylenimine cross-linked 2-hydroxypopyl-β-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA
por: Li, Jin-Ming, et al.
Publicado: (2013)

Nischarin-siRNA delivered by polyethylenimine-alginate nanoparticles accelerates motor function recovery after spinal cord injury
por: Ding, Yue-min, et al.
Publicado: (2017)

Linear polyethylenimine produced by partial acid hydrolysis of poly(2-ethyl-2-oxazoline) for DNA and siRNA delivery in vitro
por: Fernandes, Julio C, et al.
Publicado: (2013)

Performance of Pyridylthiourea‐Polyethylenimine Polyplex for siRNA‐Mediated Liver Cancer Therapy in Cell Monolayer, Spheroid, and Tumor Xenograft Models
por: Gossart, Jean Baptiste, et al.
Publicado: (2017)

Imaging Intracellular Drug/siRNA Co-Delivery by Self-Assembly Cross-Linked Polyethylenimine with Fluorescent Core-Shell Silica Nanoparticles
por: Zhang, Ruirui, et al.
Publicado: (2022)

Is hydroxyethyl starch 130/0.4 safe?
por: Haase, Nicolai, et al.
Publicado: (2012)

Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration
por: Wang, Chuandong, et al.
Publicado: (2017)

A linear polyethylenimine mediated siRNA-based therapy targeting human epidermal growth factor receptor in SPC-A1 xenograft mice
por: Zhang, Pinghai, et al.
Publicado: (2013)

Refining a Research Manuscript
por: Misra, Ambikanandan
Publicado: (2010)

Baicalin-modified polyethylenimine for miR-34a efficient and safe delivery
por: Wang, Yingying, et al.
Publicado: (2023)

Development of siRNA lipoplexes for intracellular delivery in lung cancer cells
por: Khatri, N., et al.
Publicado: (2012)

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1
por: Davis, Sarah M., et al.
Publicado: (2022)

Folic acid-functionalized polyethylenimine superparamagnetic iron oxide nanoparticles as theranostic agents for magnetic resonance imaging and PD-L1 siRNA delivery for gastric cancer
por: Luo, Xin, et al.
Publicado: (2017)

Folate-Mediated Targeted Delivery of siPLK1 by Leucine-Bearing Polyethylenimine
por: Hou, Lu, et al.
Publicado: (2020)

Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA
por: Capel, Victoria, et al.
Publicado: (2018)

Enzyme-triggered PEGylated siRNA-nanoparticles for controlled release of siRNA
por: Yingyuad, Peerada, et al.
Publicado: (2014)

Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition
por: Berezhnoy, Alexey, et al.
Publicado: (2012)

Where should siRNAs go: applicable organs for siRNA drugs
por: Ahn, Insook, et al.
Publicado: (2023)

Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles
por: Biscans, Annabelle, et al.
Publicado: (2021)

Reversal of multidrug resistance in MCF-7/Adr cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-β-cyclodextrin nanocarrier
por: Li, Jin-Ming, et al.
Publicado: (2015)

Enhanced Cancer Theranostics with Self-Assembled, Multilabeled siRNAs
por: Kozuch, Stephen D., et al.
Publicado: (2018)

Targeted Delivery of siRNA
por: Oliveira, Sabrina, et al.
Publicado: (2006)

siRNA for Influenza Therapy
por: Barik, Sailen
Publicado: (2010)

Retrovirus-delivered siRNA
por: Devroe, Eric, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_1bm9o0phrdce0cjtuvg5h0bdqc