Synthesis, antitumor activity and molecular mechanism of doxorubicin conjugated trimethyl-chitosan polymeric micelle loading Beclin1 siRNA for drug-resisted bladder cancer therapy

Herein, we describe a convenient approach for the preparation of a polymeric micelle using doxorubicin (DOX) conjugated trimethyl-chitosan (TMC) with Beclin-1 siRNA (Si-Beclin1/DOX-TMC). This micelle displayed a potent capacity for autophagy inhibition and reversed drug-resistance to DOX in BIU-87/A...

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Detalles Bibliográficos
Autores principales: Zhong, Zhou, Cheng, Zhong, Su, Dongyuan, Xu, Ting, Li, Xiang, Wu, Fengbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087860/
https://www.ncbi.nlm.nih.gov/pubmed/35547901
http://dx.doi.org/10.1039/c8ra06548a

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