Cargando…

Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer

BACKGROUND: Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role of exonic breakpoints remains elusive. We investigated whether exonic-breakpoint fusions could predict matched target...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Weihua, Wan, Rui, Guo, Lei, Chang, Geyun, Jiang, Dong, Meng, Lin, Ying, Jianming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087946/ https://www.ncbi.nlm.nih.gov/pubmed/35534835 http://dx.doi.org/10.1186/s12916-022-02362-9

Ejemplares similares

FusionAI: Predicting fusion breakpoint from DNA sequence with deep learning
por: Kim, Pora, et al.
Publicado: (2021)

Breakpoint mapping of 13 large parkin deletions/duplications reveals an exon 4 deletion and an exon 7 duplication as founder mutations
por: Elfferich, Peter, et al.
Publicado: (2011)

Fusion transcripts and their genomic breakpoints in polyadenylated and ribosomal RNA–minus RNA sequencing data
por: Hoogstrate, Youri, et al.
Publicado: (2021)

Sequence Homology at the Breakpoint and Clinical Phenotype of Mitochondrial DNA Deletion Syndromes
por: Sadikovic, Bekim, et al.
Publicado: (2010)

SoftSearch: Integration of Multiple Sequence Features to Identify Breakpoints of Structural Variations
por: Hart, Steven N., et al.
Publicado: (2013)

Routine EWS Fusion Analysis in the Oncology Clinic to Identify Cancer-Specific Peptide Sequence Patterns That Span Breakpoints in Ewing Sarcoma and DSRCT
por: Anderson, Peter M., et al.
Publicado: (2023)

Identifying Balanced Chromosomal Translocations in Human Embryos by Oxford Nanopore Sequencing and Breakpoints Region Analysis
por: Pei, Zhenle, et al.
Publicado: (2022)

Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data
por: Fernandez-Cuesta, Lynnette, et al.
Publicado: (2015)

Identifying the Important HIV-1 Recombination Breakpoints
por: Archer, John, et al.
Publicado: (2008)

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints
por: Dong, Dawei W, et al.
Publicado: (2014)

Correction: Sequence Homology at the Breakpoint and Clinical Phenotype of Mitochondrial DNA Deletion Syndromes
por: Sadikovic, Bekim, et al.
Publicado: (2017)

Correction: SoftSearch: Integration of Multiple Sequence Features to Identify Breakpoints of Structural Variations
Publicado: (2014)

Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.
por: Flibotte, Stephane, et al.
Publicado: (2021)

MitoBreak: the mitochondrial DNA breakpoints database
por: Damas, Joana, et al.
Publicado: (2014)

Genomic EWS-FLI1 Fusion Sequences in Ewing Sarcoma Resemble Breakpoint Characteristics of Immature Lymphoid Malignancies
por: Berger, Manfred, et al.
Publicado: (2013)

Tracking genome engineering outcome at individual DNA breakpoints
por: Certo, Michael T., et al.
Publicado: (2011)

Mutation spectrum of Drosophila CNVs revealed by breakpoint sequencing
por: Cardoso-Moreira, Margarida, et al.
Publicado: (2012)

Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences
por: Bacolla, Albino, et al.
Publicado: (2016)

RNA-seq Based Transcription Characterization of Fusion Breakpoints as a Potential Estimator for Its Oncogenic Potential
por: Gu, Jian-lei, et al.
Publicado: (2017)

Next-Generation Sequencing of Apoptotic DNA Breakpoints Reveals Association with Actively Transcribed Genes and Gene Translocations
por: Fullwood, Melissa J., et al.
Publicado: (2011)

Sequenced Breakpoints of Crossover Suppressor/Inversion qC1
por: Edgley, Mark L., et al.
Publicado: (2021)

Detection of pericentric inversion with breakpoint in DMD by whole genome sequencing
por: Zaum, Ann‐Kathrin, et al.
Publicado: (2022)

Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints
por: Lakshmanan, Lakshmi Narayanan, et al.
Publicado: (2021)

Exonic DNA Sequencing of ERBB4 in Bipolar Disorder
por: Goes, Fernando S., et al.
Publicado: (2011)

The prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma
por: Carvalho, Diana, et al.
Publicado: (2014)

Breakpoint Planning Method for Rice Multibreak Milling
por: Xiao, Yawen, et al.
Publicado: (2023)

Identification of genes located at breakpoints of uncharacterized chromosomal translocations by the use of chromosomal microdissection and next generation DNA sequencing
por: Campregher, Paulo V, et al.
Publicado: (2013)

Systematic investigation of the homology sequences around the human fusion gene breakpoints in pan-cancer – bioinformatics study for a potential link to MMEJ
por: Kim, Pora, et al.
Publicado: (2023)

Correlations of switch/sucrose nonfermentable complex mutations with clinical outcomes in advanced non–small cell lung cancer
por: Chang, Geyun, et al.
Publicado: (2022)

Recurrence of Chromosome Rearrangements and Reuse of DNA Breakpoints in the Evolution of the Triticeae Genomes
por: Li, Wanlong, et al.
Publicado: (2016)

RNAi technology targeting the FGFR3-TACC3 fusion breakpoint: an opportunity for precision medicine
por: Parker Kerrigan, Brittany C, et al.
Publicado: (2020)

Genome Sequence of Complex HIV-1 Unique Recombinant Forms Sharing a Common Recombination Breakpoint Identified in Malaysia
por: Cheong, Hui Ting, et al.
Publicado: (2015)

Cryptic breakpoint identified by whole-genome mate-pair sequencing in a rare paternally inherited complex chromosomal rearrangement
por: Aristidou, Constantia, et al.
Publicado: (2018)

Sequence determinants of breakpoint location during HIV-1 intersubtype recombination
por: Baird, Heather A., et al.
Publicado: (2006)

Characterization of Chromosomal Translocation Breakpoint Sequences in Solid Tumours: “An In Silico Analysis”
por: Daga, Aditi, et al.
Publicado: (2015)

Tandem Repeats and G-Rich Sequences Are Enriched at Human CNV Breakpoints
por: Bose, Promita, et al.
Publicado: (2014)

Identifying and Avoiding tcDNA-ASO Sequence-Specific Toxicity for the Development of DMD Exon 51 Skipping Therapy
por: Aupy, Philippine, et al.
Publicado: (2019)

A Fast Algorithm for Exonic Regions Prediction in DNA Sequences
por: Saberkari, Hamidreza, et al.
Publicado: (2013)

Validation of the Idylla GeneFusion assay to detect fusions and MET exon-skipping in non-small cell lung cancers
por: Gilson, Pauline, et al.
Publicado: (2023)

Antimicrobial Resistance: Beyond the Breakpoint
por: Pombo, David J.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_448c7e7ds7crpj8cfqdmv82biv