SARS‐CoV‐2 cold‐chain transmission: Characteristics, risks, and strategies

Low temperature and certain humidity are conducive to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for long‐time survival and long‐distance spread during logistics and trades. Contaminated cold‐chain or frozen products and outer packaging act as the carrier of SARS‐CoV‐2, that infects the high‐risk population who works in the ports, cold storage or seafood market. Since the coronavirus disease 2019 (COVID‐19) pandemic worldwide, multiple localized outbreaks caused by SARS‐CoV‐2 contaminated imported cold‐chain products have been reported in China, which brought challenges to COVID‐19 prevention and control. Here, we review the evidences of SARS‐CoV‐2 cold‐chain transmission from six confirmed cold‐chain related COVID‐19 outbreaks in China, especially in terms of SARS‐CoV‐2 whole‐genome sequencing and virus isolation. In addition, we summarize the characteristics and mode of SARS‐CoV‐2 cold‐chain transmission from both six COVID‐19 outbreaks in China and the outbreaks suspected cold‐chain transmission in other countries. Finally, we analyze the underlying risks of SARS‐CoV‐2 cold‐chain transmission and propose the preventive countermeasures.