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Harnessing autophagy to fight SARS‐CoV‐2: An update in view of recent drug development efforts

Drug repurposing is an attractive option for identifying new treatment strategies, in particular in extraordinary situations of urgent need such as the current coronavirus disease 2019 (Covid‐19) pandemic. Recently, the World Health Organization announced testing of three drugs as potential Covid‐19...

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Detalles Bibliográficos
Autor principal: Rein, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088732/
https://www.ncbi.nlm.nih.gov/pubmed/34668225
http://dx.doi.org/10.1002/jcb.30166
Descripción
Sumario:Drug repurposing is an attractive option for identifying new treatment strategies, in particular in extraordinary situations of urgent need such as the current coronavirus disease 2019 (Covid‐19) pandemic. Recently, the World Health Organization announced testing of three drugs as potential Covid‐19 therapeutics that are known for their dampening effect on the immune system. Thus, the underlying concept of selecting these drugs is to temper the potentially life‐threatening overshooting of the immune system reacting to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection. This viewpoint discusses the possibility that the impact of these and other drugs on autophagy contributes to their therapeutic effect by hampering the SARS‐CoV‐2 life cycle.