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Path to Actinorhodin: Regio- and Stereoselective Ketone Reduction by a Type II Polyketide Ketoreductase Revealed in Atomistic Detail

[Image: see text] In type II polyketide synthases (PKSs), which typically biosynthesize several antibiotic and antitumor compounds, the substrate is a growing polyketide chain, shuttled between individual PKS enzymes, while covalently tethered to an acyl carrier protein (ACP): this requires the ACP...

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Detalles Bibliográficos
Autores principales:	Serapian, Stefano A., Crosby, John, Crump, Matthew P., van der Kamp, Marc W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088766/ https://www.ncbi.nlm.nih.gov/pubmed/35557750 http://dx.doi.org/10.1021/jacsau.2c00086

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