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Complex Loop Dynamics Underpin Activity, Specificity, and Evolvability in the (βα)(8) Barrel Enzymes of Histidine and Tryptophan Biosynthesis

[Image: see text] Enzymes are conformationally dynamic, and their dynamical properties play an important role in regulating their specificity and evolvability. In this context, substantial attention has been paid to the role of ligand-gated conformational changes in enzyme catalysis; however, such s...

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Detalles Bibliográficos
Autores principales:	Romero-Rivera, Adrian, Corbella, Marina, Parracino, Antonietta, Patrick, Wayne M., Kamerlin, Shina Caroline Lynn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088769/ https://www.ncbi.nlm.nih.gov/pubmed/35557756 http://dx.doi.org/10.1021/jacsau.2c00063

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