Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues

Lysine-specific demethylases 1 and 2 (LSD1 and LSD2) are flavoenzyme demethylases, and their inhibitors are considered as potential chemical tools and anticancer agents. Here we report polyamine-based inhibitors of LSD1 and LSD2. In the initial screening, partially constrained polyamine 2 which cont...

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Detalles Bibliográficos
Autores principales: Umezawa, Naoki, Tsuji, Kasumi, Sato, Shin, Kikuchi, Masaki, Watanabe, Hisami, Horai, Yuhei, Yamaguchi, Masashi, Hisamatsu, Yosuke, Umehara, Takashi, Higuchi, Tsunehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088916/
https://www.ncbi.nlm.nih.gov/pubmed/35558920
http://dx.doi.org/10.1039/c8ra07879c

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