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Smad4 and p53 synergize in suppressing autochthonous intestinal cancer

BACKGROUND: Smad4 and p53 mutations are the most common mutations in human colorectal cancers (CRCs). We evaluated whether and how they are synergistic in intestinal carcinogenesis using novel autochthonous mouse models. METHOD: To recapitulate human CRCs, we generated Villin‐Cre;Smad4(F) (/) (F) ;T...

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Detalles Bibliográficos
Autores principales:	Park, Jun Won, Seo, Min‐Jung, Cho, Kye Soo, Kook, Myeong‐Cherl, Jeong, Jong Min, Roh, Seul‐Gi, Cho, Soo Young, Cheon, Jae Hee, Kim, Hark Kyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089223/ https://www.ncbi.nlm.nih.gov/pubmed/35274815 http://dx.doi.org/10.1002/cam4.4533

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