An iodine/DMSO-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1H-imidazoles from α-methylene ketones

A sequential one-pot approach to 2,4,5-trisubstituted imidazoles has been developed from α-methylene ketones and aldehydes. This methodology employs air-moisture stable reaction conditions and an inexpensive iodine/DMSO system affording a diverse range of known and novel (substrate scope) 2,4,5-tris...

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Detalles Bibliográficos
Autores principales: Jayram, Janeeka, Jeena, Vineet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089320/
https://www.ncbi.nlm.nih.gov/pubmed/35558600
http://dx.doi.org/10.1039/c8ra07238h
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author Jayram, Janeeka
Jeena, Vineet
author_facet Jayram, Janeeka
Jeena, Vineet
author_sort Jayram, Janeeka
collection PubMed
description A sequential one-pot approach to 2,4,5-trisubstituted imidazoles has been developed from α-methylene ketones and aldehydes. This methodology employs air-moisture stable reaction conditions and an inexpensive iodine/DMSO system affording a diverse range of known and novel (substrate scope) 2,4,5-trisubstituted imidazoles in moderate to excellent yields. The iodine/DMSO system was extended to the domino convergent synthesis of two functionalized intermediates, benzil and benzaldehyde, to produce the final product.
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spelling pubmed-90893202022-05-11 An iodine/DMSO-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1H-imidazoles from α-methylene ketones Jayram, Janeeka Jeena, Vineet RSC Adv Chemistry A sequential one-pot approach to 2,4,5-trisubstituted imidazoles has been developed from α-methylene ketones and aldehydes. This methodology employs air-moisture stable reaction conditions and an inexpensive iodine/DMSO system affording a diverse range of known and novel (substrate scope) 2,4,5-trisubstituted imidazoles in moderate to excellent yields. The iodine/DMSO system was extended to the domino convergent synthesis of two functionalized intermediates, benzil and benzaldehyde, to produce the final product. The Royal Society of Chemistry 2018-11-07 /pmc/articles/PMC9089320/ /pubmed/35558600 http://dx.doi.org/10.1039/c8ra07238h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Jayram, Janeeka
Jeena, Vineet
An iodine/DMSO-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1H-imidazoles from α-methylene ketones
title An iodine/DMSO-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1H-imidazoles from α-methylene ketones
title_full An iodine/DMSO-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1H-imidazoles from α-methylene ketones
title_fullStr An iodine/DMSO-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1H-imidazoles from α-methylene ketones
title_full_unstemmed An iodine/DMSO-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1H-imidazoles from α-methylene ketones
title_short An iodine/DMSO-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1H-imidazoles from α-methylene ketones
title_sort iodine/dmso-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1h-imidazoles from α-methylene ketones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089320/
https://www.ncbi.nlm.nih.gov/pubmed/35558600
http://dx.doi.org/10.1039/c8ra07238h
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