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High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells

[Image: see text] Sickle cell disease (SCD) is an inherited disorder of hemoglobin (Hb); approximately 300,000 babies are born worldwide with SCD each year. In SCD, fibers of polymerized sickle Hb (HbS) form in red blood cells (RBCs), which cause RBCs to develop their characteristic “sickled” shape,...

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Detalles Bibliográficos
Autores principales:	Nakagawa, Akito, Cooper, Marissa K., Kost-Alimova, Maria, Berstler, James, Yu, Binglan, Berra, Lorenzo, Klings, Elizabeth S., Huang, Mary S., Heeney, Matthew M., Bloch, Donald B., Zapol, Warren M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089379/ https://www.ncbi.nlm.nih.gov/pubmed/35559170 http://dx.doi.org/10.1021/acsomega.2c00541

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