Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease

BACKGROUND AND AIMS: Histone deacetylase inhibitors [HDACi] exert potent anti-inflammatory effects. Because of the ubiquitous expression of HDACs, clinical utility of HDACi is limited by off-target effects. Esterase-sensitive motif [ESM] technology aims to deliver ESM-conjugated compounds to human m...

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Detalles Bibliográficos
Autores principales: Elfiky, Ahmed M I, Ghiboub, Mohammed, Li Yim, Andrew Y F, Hageman, Ishtu L, Verhoeff, Jan, de Krijger, Manon, van Hamersveld, Patricia H P, Welting, Olaf, Admiraal, Iris, Rahman, Shafaque, Garcia-Vallejo, Juan J, Wildenberg, Manon E, Tomlinson, Laura, Gregory, Richard, Rioja, Inmaculada, Prinjha, Rab K, Furze, Rebecca C, Lewis, Huw D, Mander, Palwinder K, Heinsbroek, Sigrid E M, Bell, Matthew J, de Jonge, Wouter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089418/
https://www.ncbi.nlm.nih.gov/pubmed/34633041
http://dx.doi.org/10.1093/ecco-jcc/jjab176

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