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Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues
Epithelia are sheets of cells that communicate and coordinate their behavior in order to ensure their barrier function. Among the plethora of proteins involved in epithelial dynamics, actin nucleators play an essential role. The branched actin nucleation complex Arp2/3 has numerous functions, such a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089454/ https://www.ncbi.nlm.nih.gov/pubmed/35557951 http://dx.doi.org/10.3389/fcell.2022.886288 |
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author | Martin, Emmanuel Suzanne, Magali |
author_facet | Martin, Emmanuel Suzanne, Magali |
author_sort | Martin, Emmanuel |
collection | PubMed |
description | Epithelia are sheets of cells that communicate and coordinate their behavior in order to ensure their barrier function. Among the plethora of proteins involved in epithelial dynamics, actin nucleators play an essential role. The branched actin nucleation complex Arp2/3 has numerous functions, such as the regulation of cell-cell adhesion, intracellular trafficking, the formation of protrusions, that have been well described at the level of individual cells. Here, we chose to focus on its role in epithelial tissue, which is rising attention in recent works. We discuss how the cellular activities of the Arp2/3 complex drive epithelial dynamics and/or tissue morphogenesis. In the first part, we examined how this complex influences cell-cell cooperation at local scale in processes such as cell-cell fusion or cell corpses engulfment. In the second part, we summarized recent papers dealing with the impact of the Arp2/3 complex at larger scale, focusing on different morphogenetic events, including cell intercalation, epithelial tissue closure and epithelial folding. Altogether, this review highlights the central role of Arp2/3 in a diversity of epithelial tissue reorganization. |
format | Online Article Text |
id | pubmed-9089454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90894542022-05-11 Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues Martin, Emmanuel Suzanne, Magali Front Cell Dev Biol Cell and Developmental Biology Epithelia are sheets of cells that communicate and coordinate their behavior in order to ensure their barrier function. Among the plethora of proteins involved in epithelial dynamics, actin nucleators play an essential role. The branched actin nucleation complex Arp2/3 has numerous functions, such as the regulation of cell-cell adhesion, intracellular trafficking, the formation of protrusions, that have been well described at the level of individual cells. Here, we chose to focus on its role in epithelial tissue, which is rising attention in recent works. We discuss how the cellular activities of the Arp2/3 complex drive epithelial dynamics and/or tissue morphogenesis. In the first part, we examined how this complex influences cell-cell cooperation at local scale in processes such as cell-cell fusion or cell corpses engulfment. In the second part, we summarized recent papers dealing with the impact of the Arp2/3 complex at larger scale, focusing on different morphogenetic events, including cell intercalation, epithelial tissue closure and epithelial folding. Altogether, this review highlights the central role of Arp2/3 in a diversity of epithelial tissue reorganization. Frontiers Media S.A. 2022-04-26 /pmc/articles/PMC9089454/ /pubmed/35557951 http://dx.doi.org/10.3389/fcell.2022.886288 Text en Copyright © 2022 Martin and Suzanne. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Martin, Emmanuel Suzanne, Magali Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
title | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
title_full | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
title_fullStr | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
title_full_unstemmed | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
title_short | Functions of Arp2/3 Complex in the Dynamics of Epithelial Tissues |
title_sort | functions of arp2/3 complex in the dynamics of epithelial tissues |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089454/ https://www.ncbi.nlm.nih.gov/pubmed/35557951 http://dx.doi.org/10.3389/fcell.2022.886288 |
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