Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles

[Image: see text] A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the anili...

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Detalles Bibliográficos
Autores principales: Aksenov, Nicolai A., Aksenov, Alexander V., Prityko, Lidiya A., Aksenov, Dmitrii A., Aksenova, Daria S., Nobi, Mezvah A., Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089741/
https://www.ncbi.nlm.nih.gov/pubmed/35573208
http://dx.doi.org/10.1021/acsomega.2c01238
Descripción
Sumario:[Image: see text] A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the aniline moiety. Overall, this modification allowed for the improvement of yields and expansion of the reaction scope.

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