Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles

[Image: see text] A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the anili...

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Autores principales: Aksenov, Nicolai A., Aksenov, Alexander V., Prityko, Lidiya A., Aksenov, Dmitrii A., Aksenova, Daria S., Nobi, Mezvah A., Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089741/
https://www.ncbi.nlm.nih.gov/pubmed/35573208
http://dx.doi.org/10.1021/acsomega.2c01238
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author Aksenov, Nicolai A.
Aksenov, Alexander V.
Prityko, Lidiya A.
Aksenov, Dmitrii A.
Aksenova, Daria S.
Nobi, Mezvah A.
Rubin, Michael
author_facet Aksenov, Nicolai A.
Aksenov, Alexander V.
Prityko, Lidiya A.
Aksenov, Dmitrii A.
Aksenova, Daria S.
Nobi, Mezvah A.
Rubin, Michael
author_sort Aksenov, Nicolai A.
collection PubMed
description [Image: see text] A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the aniline moiety. Overall, this modification allowed for the improvement of yields and expansion of the reaction scope.
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spelling pubmed-90897412022-05-12 Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles Aksenov, Nicolai A. Aksenov, Alexander V. Prityko, Lidiya A. Aksenov, Dmitrii A. Aksenova, Daria S. Nobi, Mezvah A. Rubin, Michael ACS Omega [Image: see text] A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the aniline moiety. Overall, this modification allowed for the improvement of yields and expansion of the reaction scope. American Chemical Society 2022-04-15 /pmc/articles/PMC9089741/ /pubmed/35573208 http://dx.doi.org/10.1021/acsomega.2c01238 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Aksenov, Nicolai A.
Aksenov, Alexander V.
Prityko, Lidiya A.
Aksenov, Dmitrii A.
Aksenova, Daria S.
Nobi, Mezvah A.
Rubin, Michael
Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
title Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
title_full Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
title_fullStr Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
title_full_unstemmed Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
title_short Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles
title_sort oxidative cyclization of 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-oxoindolin-2-ylidene)acetonitriles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089741/
https://www.ncbi.nlm.nih.gov/pubmed/35573208
http://dx.doi.org/10.1021/acsomega.2c01238
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