Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones

[Image: see text] An efficient and novel photoinduced trifluoromethylation employing CF(3)Br as a trifluoromethyl source is described. With commercially accessible fac-Ir((III))(ppy)(3) as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF(3)Br occurs successfully. This met...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Ransong, Deng, Zhoubin, Wang, Ke-Hu, Wang, Junjiao, Huang, Danfeng, Su, Yingpeng, Hu, Yulai, Lv, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089747/
https://www.ncbi.nlm.nih.gov/pubmed/35573213
http://dx.doi.org/10.1021/acsomega.2c01241
Descripción
Sumario:[Image: see text] An efficient and novel photoinduced trifluoromethylation employing CF(3)Br as a trifluoromethyl source is described. With commercially accessible fac-Ir((III))(ppy)(3) as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF(3)Br occurs successfully. This method provides various α-CF(3)-substituted ketones with a broad substrate scope in good yields under mild reaction conditions.

Ejemplares similares