Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones

[Image: see text] An efficient and novel photoinduced trifluoromethylation employing CF(3)Br as a trifluoromethyl source is described. With commercially accessible fac-Ir((III))(ppy)(3) as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF(3)Br occurs successfully. This met...

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Autores principales: Ma, Ransong, Deng, Zhoubin, Wang, Ke-Hu, Wang, Junjiao, Huang, Danfeng, Su, Yingpeng, Hu, Yulai, Lv, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089747/
https://www.ncbi.nlm.nih.gov/pubmed/35573213
http://dx.doi.org/10.1021/acsomega.2c01241
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author Ma, Ransong
Deng, Zhoubin
Wang, Ke-Hu
Wang, Junjiao
Huang, Danfeng
Su, Yingpeng
Hu, Yulai
Lv, Xiaobo
author_facet Ma, Ransong
Deng, Zhoubin
Wang, Ke-Hu
Wang, Junjiao
Huang, Danfeng
Su, Yingpeng
Hu, Yulai
Lv, Xiaobo
author_sort Ma, Ransong
collection PubMed
description [Image: see text] An efficient and novel photoinduced trifluoromethylation employing CF(3)Br as a trifluoromethyl source is described. With commercially accessible fac-Ir((III))(ppy)(3) as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF(3)Br occurs successfully. This method provides various α-CF(3)-substituted ketones with a broad substrate scope in good yields under mild reaction conditions.
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spelling pubmed-90897472022-05-12 Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones Ma, Ransong Deng, Zhoubin Wang, Ke-Hu Wang, Junjiao Huang, Danfeng Su, Yingpeng Hu, Yulai Lv, Xiaobo ACS Omega [Image: see text] An efficient and novel photoinduced trifluoromethylation employing CF(3)Br as a trifluoromethyl source is described. With commercially accessible fac-Ir((III))(ppy)(3) as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF(3)Br occurs successfully. This method provides various α-CF(3)-substituted ketones with a broad substrate scope in good yields under mild reaction conditions. American Chemical Society 2022-04-12 /pmc/articles/PMC9089747/ /pubmed/35573213 http://dx.doi.org/10.1021/acsomega.2c01241 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Ma, Ransong
Deng, Zhoubin
Wang, Ke-Hu
Wang, Junjiao
Huang, Danfeng
Su, Yingpeng
Hu, Yulai
Lv, Xiaobo
Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones
title Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones
title_full Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones
title_fullStr Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones
title_full_unstemmed Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones
title_short Photoinduced Trifluoromethylation with CF(3)Br as a Trifluoromethyl Source: Synthesis of α-CF(3)-Substituted Ketones
title_sort photoinduced trifluoromethylation with cf(3)br as a trifluoromethyl source: synthesis of α-cf(3)-substituted ketones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089747/
https://www.ncbi.nlm.nih.gov/pubmed/35573213
http://dx.doi.org/10.1021/acsomega.2c01241
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