Rasa3 deficiency minimally affects thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance

Platelet homeostasis is dependent on a tight regulation of both platelet production and clearance. The small GTPase Rap1 mediates platelet adhesion and hemostatic plug formation. However, Rap1 signaling is also critical for platelet homeostasis as both Rap1 deficiency and uninhibited Rap1 signaling...

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Detalles Bibliográficos
Autores principales: Lee, Robert H., Ghalloussi, Dorsaf, Harousseau, Gabriel L., Kenny, Joseph P., Kramer, Patrick A., Proamer, Fabienne, Nieswandt, Bernhard, Flick, Matthew J., Gachet, Christian, Casari, Caterina, Eckly, Anita, Bergmeier, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089782/
https://www.ncbi.nlm.nih.gov/pubmed/35290242
http://dx.doi.org/10.1172/jci.insight.155676

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