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Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants

Most therapeutic mAbs target the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. Unfortunately, the RBD is a hot spot for mutations in SARS-CoV-2 variants, which will lead to loss of the neutralizing function of current therapeutic mAbs. Universal mAbs for different variants are ne...

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Detalles Bibliográficos
Autores principales:	Wu, Wan-Ling, Chiang, Chen-Yi, Lai, Szu-Chia, Yu, Chia-Yi, Huang, Yu-Ling, Liao, Hung-Chun, Liao, Ching-Len, Chen, Hsin-Wei, Liu, Shih-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089791/ https://www.ncbi.nlm.nih.gov/pubmed/35290246 http://dx.doi.org/10.1172/jci.insight.157597

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