Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex

Systemic sclerosis (SSc) is a fibrotic autoimmune disease characterized by pathogenic activation of fibroblasts enhanced by local oxidative stress. The tyrosine phosphatase PTP4A1 was identified as a critical promoter of TGF-β signaling in SSc. Oxidative stress is known to functionally inactivate ty...

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Detalles Bibliográficos
Autores principales: Zhang, Ruiyuan, Kumar, Ganesan Senthil, Hansen, Uwe, Zoccheddu, Martina, Sacchetti, Cristiano, Holmes, Zachary J., Lee, Megan C., Beckmann, Denise, Wen, Yutao, Mikulski, Zbigniew, Yang, Shen, Santelli, Eugenio, Page, Rebecca, Boin, Francesco, Peti, Wolfgang, Bottini, Nunzio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089796/
https://www.ncbi.nlm.nih.gov/pubmed/35451370
http://dx.doi.org/10.1172/jci.insight.155761

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