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Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams

In this study, we report our experience in commissioning a commercial treatment planning system (TPS) for fast-raster scanning of carbon-ion beams. This TPS uses an analytical dose calculation algorithm, a pencil-beam model with a triple Gaussian form for the lateral-dose distribution, and a beam sp...

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Autores principales: Yagi, Masashi, Tsubouchi, Toshiro, Hamatani, Noriaki, Takashina, Masaaki, Maruo, Hiroyasu, Fujitaka, Shinichiro, Nihongi, Hideaki, Ogawa, Kazuhiko, Kanai, Tatsuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089877/
https://www.ncbi.nlm.nih.gov/pubmed/35536852
http://dx.doi.org/10.1371/journal.pone.0268087
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author Yagi, Masashi
Tsubouchi, Toshiro
Hamatani, Noriaki
Takashina, Masaaki
Maruo, Hiroyasu
Fujitaka, Shinichiro
Nihongi, Hideaki
Ogawa, Kazuhiko
Kanai, Tatsuaki
author_facet Yagi, Masashi
Tsubouchi, Toshiro
Hamatani, Noriaki
Takashina, Masaaki
Maruo, Hiroyasu
Fujitaka, Shinichiro
Nihongi, Hideaki
Ogawa, Kazuhiko
Kanai, Tatsuaki
author_sort Yagi, Masashi
collection PubMed
description In this study, we report our experience in commissioning a commercial treatment planning system (TPS) for fast-raster scanning of carbon-ion beams. This TPS uses an analytical dose calculation algorithm, a pencil-beam model with a triple Gaussian form for the lateral-dose distribution, and a beam splitting algorithm to consider lateral heterogeneity in a medium. We adopted the mixed beam model as the relative biological effectiveness (RBE) model for calculating the RBE values of the scanned carbon-ion beam. To validate the modeled physical dose, we compared the calculations with measurements of various relevant quantities as functions of the field size, range and width of the spread-out Bragg peak (SOBP), and depth–dose and lateral-dose profiles for a 6-mm SOBP in water. To model the biological dose, we compared the RBE calculated with the newly developed TPS to the RBE calculated with a previously validated TPS that is in clinical use and uses the same RBE model concept. We also performed patient-specific measurements to validate the dose model in clinical situations. The physical beam model reproduces the measured absolute dose at the center of the SOBP as a function of field size, range, and SOBP width and reproduces the dose profiles for a 6-mm SOBP in water. However, the profiles calculated for a heterogeneous phantom have some limitations in predicting the carbon-ion-beam dose, although the biological doses agreed well with the values calculated by the validated TPS. Using this dose model for fast-raster scanning, we successfully treated more than 900 patients from October 2018 to October 2020, with an acceptable agreement between the TPS-calculated and measured dose distributions. We conclude that the newly developed TPS can be used clinically with the understanding that it has limited accuracies for heterogeneous media.
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spelling pubmed-90898772022-05-11 Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams Yagi, Masashi Tsubouchi, Toshiro Hamatani, Noriaki Takashina, Masaaki Maruo, Hiroyasu Fujitaka, Shinichiro Nihongi, Hideaki Ogawa, Kazuhiko Kanai, Tatsuaki PLoS One Research Article In this study, we report our experience in commissioning a commercial treatment planning system (TPS) for fast-raster scanning of carbon-ion beams. This TPS uses an analytical dose calculation algorithm, a pencil-beam model with a triple Gaussian form for the lateral-dose distribution, and a beam splitting algorithm to consider lateral heterogeneity in a medium. We adopted the mixed beam model as the relative biological effectiveness (RBE) model for calculating the RBE values of the scanned carbon-ion beam. To validate the modeled physical dose, we compared the calculations with measurements of various relevant quantities as functions of the field size, range and width of the spread-out Bragg peak (SOBP), and depth–dose and lateral-dose profiles for a 6-mm SOBP in water. To model the biological dose, we compared the RBE calculated with the newly developed TPS to the RBE calculated with a previously validated TPS that is in clinical use and uses the same RBE model concept. We also performed patient-specific measurements to validate the dose model in clinical situations. The physical beam model reproduces the measured absolute dose at the center of the SOBP as a function of field size, range, and SOBP width and reproduces the dose profiles for a 6-mm SOBP in water. However, the profiles calculated for a heterogeneous phantom have some limitations in predicting the carbon-ion-beam dose, although the biological doses agreed well with the values calculated by the validated TPS. Using this dose model for fast-raster scanning, we successfully treated more than 900 patients from October 2018 to October 2020, with an acceptable agreement between the TPS-calculated and measured dose distributions. We conclude that the newly developed TPS can be used clinically with the understanding that it has limited accuracies for heterogeneous media. Public Library of Science 2022-05-10 /pmc/articles/PMC9089877/ /pubmed/35536852 http://dx.doi.org/10.1371/journal.pone.0268087 Text en © 2022 Yagi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yagi, Masashi
Tsubouchi, Toshiro
Hamatani, Noriaki
Takashina, Masaaki
Maruo, Hiroyasu
Fujitaka, Shinichiro
Nihongi, Hideaki
Ogawa, Kazuhiko
Kanai, Tatsuaki
Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams
title Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams
title_full Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams
title_fullStr Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams
title_full_unstemmed Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams
title_short Commissioning a newly developed treatment planning system, VQA Plan, for fast-raster scanning of carbon-ion beams
title_sort commissioning a newly developed treatment planning system, vqa plan, for fast-raster scanning of carbon-ion beams
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089877/
https://www.ncbi.nlm.nih.gov/pubmed/35536852
http://dx.doi.org/10.1371/journal.pone.0268087
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