Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment

Gene therapy involves a substantial loss of hematopoietic stem and progenitor cells (HSPC) during processing and homing. Intra-BM (i.b.m.) transplantation can reduce homing losses, but prior studies have not yielded promising results. We studied the mechanisms involved in homing and engraftment of i...

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Detalles Bibliográficos
Autores principales: Felker, Sydney, Shrestha, Archana, Bailey, Jeff, Pillis, Devin M, Siniard, Dylan, Malik, Punam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090236/
https://www.ncbi.nlm.nih.gov/pubmed/35531956
http://dx.doi.org/10.1172/jci.insight.151847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090236/
https://www.ncbi.nlm.nih.gov/pubmed/35531956
http://dx.doi.org/10.1172/jci.insight.151847

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