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Modeling buprenorphine reduction of fentanyl-induced respiratory depression

BACKGROUND: Potent synthetic opioids, such as fentanyl, are increasingly abused, resulting in unprecedented numbers of fatalities from respiratory depression. Treatment with the high-affinity mu-opioid receptor partial agonist buprenorphine may prevent fatalities by reducing binding of potent opioid...

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Detalles Bibliográficos
Autores principales:	Olofsen, Erik, Algera, Marijke Hyke, Moss, Laurence, Dobbins, Robert L., Groeneveld, Geert J., van Velzen, Monique, Niesters, Marieke, Dahan, Albert, Laffont, Celine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090248/ https://www.ncbi.nlm.nih.gov/pubmed/35316224 http://dx.doi.org/10.1172/jci.insight.156973

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