IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function

BACKGROUND: Some clinical features of severe COVID-19 represent blood vessel damage induced by activation of host immune responses initiated by the coronavirus SARS-CoV-2. We hypothesized autoantibodies against angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor expressed on vascular end...

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Detalles Bibliográficos
Autores principales: Casciola-Rosen, Livia, Thiemann, David R., Andrade, Felipe, Trejo-Zambrano, Maria I., Leonard, Elissa K., Spangler, Jamie B., Skinner, Nicole E., Bailey, Justin, Yegnasubramanian, Srinivasan, Wang, Rulin, Vaghasia, Ajay M., Gupta, Anuj, Cox, Andrea L., Ray, Stuart C., Linville, Raleigh M., Guo, Zhaobin, Searson, Peter C., Machamer, Carolyn E., Desiderio, Stephen, Sauer, Lauren M., Laeyendecker, Oliver, Garibaldi, Brian T., Gao, Li, Damarla, Mahendra, Hassoun, Paul M., Hooper, Jody E., Mecoli, Christopher A., Christopher-Stine, Lisa, Gutierrez-Alamillo, Laura, Yang, Qingyuan, Hines, David, Clarke, William A., Rothman, Richard E., Pekosz, Andrew, Fenstermacher, Katherine Z.J., Wang, Zitong, Zeger, Scott L., Rosen, Antony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090251/
https://www.ncbi.nlm.nih.gov/pubmed/35349483
http://dx.doi.org/10.1172/jci.insight.158362

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