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Neuropilin-1 deficiency in vascular smooth muscle cells is associated with hereditary hemorrhagic telangiectasia arteriovenous malformations

Patients with hereditary hemorrhagic telangiectasia (HHT) have arteriovenous malformations (AVMs) with genetic mutations involving the activin-A receptor like type 1 (ACVRL1 or ALK1) and endoglin (ENG). Recent studies have shown that Neuropilin-1 (NRP-1) inhibits ALK1. We investigated the expression...

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Detalles Bibliográficos
Autores principales:	Kilari, Sreenivasulu, Wang, Ying, Singh, Avishek, Graham, Rondell P., Iyer, Vivek, Thompson, Scott M., Torbenson, Michael S., Mukhopadhyay, Debabrata, Misra, Sanjay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090252/ https://www.ncbi.nlm.nih.gov/pubmed/35380991 http://dx.doi.org/10.1172/jci.insight.155565

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