Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell–specific manner

Hematopoietic protein-1 (Hem-1) is a member of the actin-regulatory WASp family verprolin homolog (WAVE) complex. Loss-of-function variants in the NCKAP1L gene encoding Hem-1 were recently discovered to result in primary immunodeficiency disease (PID) in children, characterized by poor specific Ab r...

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Detalles Bibliográficos
Autores principales: Avalos, Alan, Tietsort, Jacob T., Suwankitwat, Nutthakarn, Woods, Jonathan D., Jackson, Shaun W., Christodoulou, Alexandra, Morrill, Christopher, Liggitt, H. Denny, Zhu, Chengsong, Li, Quan-Zhen, Bui, Kevin K., Park, Heon, Iritani, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090261/
https://www.ncbi.nlm.nih.gov/pubmed/35531955
http://dx.doi.org/10.1172/jci.insight.153597

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