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Widespread nociceptive maps in the human neonatal somatosensory cortex
Topographic cortical maps are essential for spatial localisation of sensory stimulation and generation of appropriate task-related motor responses. Somatosensation and nociception are finely mapped and aligned in the adult somatosensory (S1) cortex, but in infancy, when pain behaviour is disorganise...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090328/ https://www.ncbi.nlm.nih.gov/pubmed/35451960 http://dx.doi.org/10.7554/eLife.71655 |
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author | Jones, Laura Verriotis, Madeleine Cooper, Robert J Laudiano-Dray, Maria Pureza Rupawala, Mohammed Meek, Judith Fabrizi, Lorenzo Fitzgerald, Maria |
author_facet | Jones, Laura Verriotis, Madeleine Cooper, Robert J Laudiano-Dray, Maria Pureza Rupawala, Mohammed Meek, Judith Fabrizi, Lorenzo Fitzgerald, Maria |
author_sort | Jones, Laura |
collection | PubMed |
description | Topographic cortical maps are essential for spatial localisation of sensory stimulation and generation of appropriate task-related motor responses. Somatosensation and nociception are finely mapped and aligned in the adult somatosensory (S1) cortex, but in infancy, when pain behaviour is disorganised and poorly directed, nociceptive maps may be less refined. We compared the topographic pattern of S1 activation following noxious (clinically required heel lance) and innocuous (touch) mechanical stimulation of the same skin region in newborn infants (n = 32) using multioptode functional near-infrared spectroscopy (fNIRS). Within S1 cortex, touch and lance of the heel elicit localised, partially overlapping increases in oxygenated haemoglobin concentration (Δ[HbO]), but while touch activation was restricted to the heel area, lance activation extended into cortical hand regions. The data reveals a widespread cortical nociceptive map in infant S1, consistent with their poorly directed pain behaviour. |
format | Online Article Text |
id | pubmed-9090328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-90903282022-05-11 Widespread nociceptive maps in the human neonatal somatosensory cortex Jones, Laura Verriotis, Madeleine Cooper, Robert J Laudiano-Dray, Maria Pureza Rupawala, Mohammed Meek, Judith Fabrizi, Lorenzo Fitzgerald, Maria eLife Neuroscience Topographic cortical maps are essential for spatial localisation of sensory stimulation and generation of appropriate task-related motor responses. Somatosensation and nociception are finely mapped and aligned in the adult somatosensory (S1) cortex, but in infancy, when pain behaviour is disorganised and poorly directed, nociceptive maps may be less refined. We compared the topographic pattern of S1 activation following noxious (clinically required heel lance) and innocuous (touch) mechanical stimulation of the same skin region in newborn infants (n = 32) using multioptode functional near-infrared spectroscopy (fNIRS). Within S1 cortex, touch and lance of the heel elicit localised, partially overlapping increases in oxygenated haemoglobin concentration (Δ[HbO]), but while touch activation was restricted to the heel area, lance activation extended into cortical hand regions. The data reveals a widespread cortical nociceptive map in infant S1, consistent with their poorly directed pain behaviour. eLife Sciences Publications, Ltd 2022-04-22 /pmc/articles/PMC9090328/ /pubmed/35451960 http://dx.doi.org/10.7554/eLife.71655 Text en © 2022, Jones et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Jones, Laura Verriotis, Madeleine Cooper, Robert J Laudiano-Dray, Maria Pureza Rupawala, Mohammed Meek, Judith Fabrizi, Lorenzo Fitzgerald, Maria Widespread nociceptive maps in the human neonatal somatosensory cortex |
title | Widespread nociceptive maps in the human neonatal somatosensory cortex |
title_full | Widespread nociceptive maps in the human neonatal somatosensory cortex |
title_fullStr | Widespread nociceptive maps in the human neonatal somatosensory cortex |
title_full_unstemmed | Widespread nociceptive maps in the human neonatal somatosensory cortex |
title_short | Widespread nociceptive maps in the human neonatal somatosensory cortex |
title_sort | widespread nociceptive maps in the human neonatal somatosensory cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090328/ https://www.ncbi.nlm.nih.gov/pubmed/35451960 http://dx.doi.org/10.7554/eLife.71655 |
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