SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous termin...

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Detalles Bibliográficos
Autores principales: Demange, Pascal, Joly, Etienne, Marcoux, Julien, Zanon, Patrick RA, Listunov, Dymytrii, Rullière, Pauline, Barthes, Cécile, Noirot, Céline, Izquierdo, Jean-Baptiste, Rozié, Alexandrine, Pradines, Karen, Hee, Romain, de Brito, Maria Vieira, Marcellin, Marlène, Serre, Remy-Felix, Bouchez, Olivier, Burlet-Schiltz, Odile, Oliveira, Maria Conceição Ferreira, Ballereau, Stéphanie, Bernardes-Génisson, Vania, Maraval, Valérie, Calsou, Patrick, Hacker, Stephan M, Génisson, Yves, Chauvin, Remi, Britton, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090334/
https://www.ncbi.nlm.nih.gov/pubmed/35535493
http://dx.doi.org/10.7554/eLife.73913

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