Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity

Triptolide (TP), a compound isolated from a Chinese medicinal herb, possesses potent anti-tumor, immunosuppressive, and anti-inflammatory properties, but was clinically limited due to its poor solubility, bioavailability, and toxicity. Considering the environment-friendly, low-cost mechanochemical t...

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Detalles Bibliográficos
Autores principales: Zhu, Dabu, Zhang, Qiuqin, Chen, Yifang, Xie, Minghua, Li, Jianbo, Yao, Shen, Li, Ming, Lou, Zhao, Cai, Yue, Sun, Xuanrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090408/
https://www.ncbi.nlm.nih.gov/pubmed/35532137
http://dx.doi.org/10.1080/10717544.2022.2069879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090408/
https://www.ncbi.nlm.nih.gov/pubmed/35532137
http://dx.doi.org/10.1080/10717544.2022.2069879

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