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Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase

Malaria is caused by infection with protozoan parasites of the Plasmodium genus, which is part of the phylum Apicomplexa. Most organisms in this phylum contain a relic plastid called the apicoplast. The apicoplast genome is replicated by a single DNA polymerase (apPOL), which is an attractive target...

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Detalles Bibliográficos
Autores principales:	Kaur, Supreet, Nieto, Nicholas S., McDonald, Peter, Beck, Josh R., Honzatko, Richard B., Roy, Anuradha, Nelson, Scott W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090415/ https://www.ncbi.nlm.nih.gov/pubmed/35514163 http://dx.doi.org/10.1080/14756366.2022.2070909

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