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Clinical and Economic Evaluation of Transdermal Oxybutynin in the Treatment of Overactive Bladder in Spain

Background: This study evaluated the clinical outcomes and economic results of transdermal oxybutynin compared to fesoterodine, tolterodine, solifenacin, oxybutynin, trospium chloride, and mirabegron for overactive bladder syndrome in Spain. Materials and Methods: A Markov model was built with month...

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Autores principales: Crespo, Carlos, Blasco, Pedro, Guigini, Marcelo, Galván, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia Data Analytics, LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090463/
https://www.ncbi.nlm.nih.gov/pubmed/35620774
http://dx.doi.org/10.36469/9811
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author Crespo, Carlos
Blasco, Pedro
Guigini, Marcelo
Galván, Jordi
author_facet Crespo, Carlos
Blasco, Pedro
Guigini, Marcelo
Galván, Jordi
author_sort Crespo, Carlos
collection PubMed
description Background: This study evaluated the clinical outcomes and economic results of transdermal oxybutynin compared to fesoterodine, tolterodine, solifenacin, oxybutynin, trospium chloride, and mirabegron for overactive bladder syndrome in Spain. Materials and Methods: A Markov model was built with monthly cycles for a 5-year time frame. The model reflected clinical events, discontinuation, dose scaling and change in treatment according to actual clinical practice. Based on experts’ opinion and the literature, the use of resources and Spanish costs were incorporated into the model. The measure of efficiency used was the cost per quality-adjusted life year (QALY) gained. The economic evaluation was performed from the perspective of the Spanish healthcare system, discounting costs (€2017) and effects at 3%. The robustness of the results was validated with a deterministic and probabilistic sensitivity analysis. Results: After a year, transdermal oxybutynin was seen to have greater persistence deriving from its better risk/benefit balance compared to muscarinic antagonists and mirabegron (55% transdermal oxybutynin, 33% mirabegron, 25% tolterodine, 27% fesoterodine, 25% solifenacin, 23% trospium chloride and 17% oxybutynin). At 5-years, better persistence resulted in improvements in QALY gained by transdermal oxybutynin of 0.050, 0.040, 0.039, 0.038, 0.034 and 0.010 compared to oxybutynin, fesoterodine, solifenacin, trospium chloride, tolterodine and mirabegron, respectively. The incremental cost–effectiveness ratio of transdermal oxybutynin ranged from €1313.96 per QALY gained compared to fesoterodine to €14 101.57 per QALY gained compared to trospium chloride. Conclusions: Kentera® (transdermal oxybutynin) is a cost–effective treatment in overactive bladder syndrome compared to muscarinic antagonists and mirabegron.
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spelling pubmed-90904632022-05-25 Clinical and Economic Evaluation of Transdermal Oxybutynin in the Treatment of Overactive Bladder in Spain Crespo, Carlos Blasco, Pedro Guigini, Marcelo Galván, Jordi J Health Econ Outcomes Res Urological/Gynecological Diseases Background: This study evaluated the clinical outcomes and economic results of transdermal oxybutynin compared to fesoterodine, tolterodine, solifenacin, oxybutynin, trospium chloride, and mirabegron for overactive bladder syndrome in Spain. Materials and Methods: A Markov model was built with monthly cycles for a 5-year time frame. The model reflected clinical events, discontinuation, dose scaling and change in treatment according to actual clinical practice. Based on experts’ opinion and the literature, the use of resources and Spanish costs were incorporated into the model. The measure of efficiency used was the cost per quality-adjusted life year (QALY) gained. The economic evaluation was performed from the perspective of the Spanish healthcare system, discounting costs (€2017) and effects at 3%. The robustness of the results was validated with a deterministic and probabilistic sensitivity analysis. Results: After a year, transdermal oxybutynin was seen to have greater persistence deriving from its better risk/benefit balance compared to muscarinic antagonists and mirabegron (55% transdermal oxybutynin, 33% mirabegron, 25% tolterodine, 27% fesoterodine, 25% solifenacin, 23% trospium chloride and 17% oxybutynin). At 5-years, better persistence resulted in improvements in QALY gained by transdermal oxybutynin of 0.050, 0.040, 0.039, 0.038, 0.034 and 0.010 compared to oxybutynin, fesoterodine, solifenacin, trospium chloride, tolterodine and mirabegron, respectively. The incremental cost–effectiveness ratio of transdermal oxybutynin ranged from €1313.96 per QALY gained compared to fesoterodine to €14 101.57 per QALY gained compared to trospium chloride. Conclusions: Kentera® (transdermal oxybutynin) is a cost–effective treatment in overactive bladder syndrome compared to muscarinic antagonists and mirabegron. Columbia Data Analytics, LLC 2018-01-09 /pmc/articles/PMC9090463/ /pubmed/35620774 http://dx.doi.org/10.36469/9811 Text en https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (4.0) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Urological/Gynecological Diseases
Crespo, Carlos
Blasco, Pedro
Guigini, Marcelo
Galván, Jordi
Clinical and Economic Evaluation of Transdermal Oxybutynin in the Treatment of Overactive Bladder in Spain
title Clinical and Economic Evaluation of Transdermal Oxybutynin in the Treatment of Overactive Bladder in Spain
title_full Clinical and Economic Evaluation of Transdermal Oxybutynin in the Treatment of Overactive Bladder in Spain
title_fullStr Clinical and Economic Evaluation of Transdermal Oxybutynin in the Treatment of Overactive Bladder in Spain
title_full_unstemmed Clinical and Economic Evaluation of Transdermal Oxybutynin in the Treatment of Overactive Bladder in Spain
title_short Clinical and Economic Evaluation of Transdermal Oxybutynin in the Treatment of Overactive Bladder in Spain
title_sort clinical and economic evaluation of transdermal oxybutynin in the treatment of overactive bladder in spain
topic Urological/Gynecological Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090463/
https://www.ncbi.nlm.nih.gov/pubmed/35620774
http://dx.doi.org/10.36469/9811
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