Cyperane and eudesmane-type sesquiterpenoids from Chinese liverwort and their anti-diabetic nephropathy potential

Six new sesquiterpenoids, including cyperane (1 and 2) and eudesmane (3–6) types, and one known eudesmane derivative (7), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis (Schrad.) Nees. The structures of 1–7 were determined based on a combination of their spectroscopi...

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Detalles Bibliográficos
Autores principales: Zhang, Jiaozhen, Wang, Yongjie, Zhu, Rongxiu, Li, Yi, Li, Yuelan, Qiao, Yanan, Zhou, Jinchuan, Lou, Hongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090610/
https://www.ncbi.nlm.nih.gov/pubmed/35558307
http://dx.doi.org/10.1039/c8ra08125e
Descripción
Sumario:Six new sesquiterpenoids, including cyperane (1 and 2) and eudesmane (3–6) types, and one known eudesmane derivative (7), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis (Schrad.) Nees. The structures of 1–7 were determined based on a combination of their spectroscopic data (NMR, HRESIMS and IR), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. Preliminary anti-diabetic nephropathy activity testing showed that the cyperane-type sesquiterpenoids could inhibit cell proliferation and extracellular matrix accumulation in high glucose cultured mesangial cells in a dose-dependent manner.

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