A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles

Heterocyclic aromatic compounds containing an imine (C[double bond, length as m-dash]N) bond such as benzimidazoles and benzothiazoles are important active pharmaceutical ingredients. The synthesis of 2-aryl-1H-benzimidazoles and 2-arylbenzothiazoles in good to excellent yields was achieved by react...

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Autores principales: Maphupha, Mudzuli, Juma, Wanyama P., de Koning, Charles B., Brady, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090715/
https://www.ncbi.nlm.nih.gov/pubmed/35558053
http://dx.doi.org/10.1039/c8ra07377e
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author Maphupha, Mudzuli
Juma, Wanyama P.
de Koning, Charles B.
Brady, Dean
author_facet Maphupha, Mudzuli
Juma, Wanyama P.
de Koning, Charles B.
Brady, Dean
author_sort Maphupha, Mudzuli
collection PubMed
description Heterocyclic aromatic compounds containing an imine (C[double bond, length as m-dash]N) bond such as benzimidazoles and benzothiazoles are important active pharmaceutical ingredients. The synthesis of 2-aryl-1H-benzimidazoles and 2-arylbenzothiazoles in good to excellent yields was achieved by reacting 2-aminoaromatics with various benzaldehyde derivatives catalysed by the commercial laccases Novoprime and Suberase® at room temperature and in the presence of atmospheric oxygen.
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spelling pubmed-90907152022-05-11 A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles Maphupha, Mudzuli Juma, Wanyama P. de Koning, Charles B. Brady, Dean RSC Adv Chemistry Heterocyclic aromatic compounds containing an imine (C[double bond, length as m-dash]N) bond such as benzimidazoles and benzothiazoles are important active pharmaceutical ingredients. The synthesis of 2-aryl-1H-benzimidazoles and 2-arylbenzothiazoles in good to excellent yields was achieved by reacting 2-aminoaromatics with various benzaldehyde derivatives catalysed by the commercial laccases Novoprime and Suberase® at room temperature and in the presence of atmospheric oxygen. The Royal Society of Chemistry 2018-11-27 /pmc/articles/PMC9090715/ /pubmed/35558053 http://dx.doi.org/10.1039/c8ra07377e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Maphupha, Mudzuli
Juma, Wanyama P.
de Koning, Charles B.
Brady, Dean
A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles
title A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles
title_full A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles
title_fullStr A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles
title_full_unstemmed A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles
title_short A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles
title_sort modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090715/
https://www.ncbi.nlm.nih.gov/pubmed/35558053
http://dx.doi.org/10.1039/c8ra07377e
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