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Nuclear soluble cGAS senses double-stranded DNA virus infection

The DNA sensor cGAS detects cytosolic DNA and instigates type I interferon (IFN) expression. Recent studies find that cGAS also localizes in the nucleus and binds the chromatin. Despite the mechanism controlling nuclear cGAS activation is well elucidated, whether nuclear cGAS participates in DNA sen...

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Detalles Bibliográficos
Autores principales:	Wu, Yakun, Song, Kun, Hao, Wenzhuo, Li, Jack, Wang, Lingyan, Li, Shitao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090744/ https://www.ncbi.nlm.nih.gov/pubmed/35538147 http://dx.doi.org/10.1038/s42003-022-03400-1

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