Cargando…

CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer

BACKGROUND: Response to immune checkpoint blockade (ICB) in ovarian cancer remains disappointing. Several studies have identified the chemokine CXCL9 as a robust prognosticator of improved survival in ovarian cancer and a characteristic of the immunoreactive subtype, which predicts ICB response. How...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seitz, Stefanie, Dreyer, Tobias F., Stange, Christoph, Steiger, Katja, Bräuer, Rosalinde, Scheutz, Leandra, Multhoff, Gabriele, Weichert, Wilko, Kiechle, Marion, Magdolen, Viktor, Bronger, Holger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090786/ https://www.ncbi.nlm.nih.gov/pubmed/35314795 http://dx.doi.org/10.1038/s41416-022-01763-0

Ejemplares similares

Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells
por: Bronger, Holger, et al.
Publicado: (2017)

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer
por: Gong, Weiwei, et al.
Publicado: (2020)

Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors
por: Bronger, Holger, et al.
Publicado: (2019)

CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer
por: Bronger, Holger, et al.
Publicado: (2016)

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer
por: Geng, Xiaocong, et al.
Publicado: (2017)

Interassay and interobserver comparability study of four programmed death-ligand 1 (PD-L1) immunohistochemistry assays in triple-negative breast cancer
por: Noske, Aurelia, et al.
Publicado: (2021)

Risk stratification in luminal-type breast cancer: Comparison of Ki-67 with EndoPredict test results
por: Noske, Aurelia, et al.
Publicado: (2019)

Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients
por: Gong, Weiwei, et al.
Publicado: (2019)

Independent Tissue-Based Biomarkers in Endometrioid Endometrial Cancer: Tumor Budding in Microsatellite Instability and WHO Grading in Copy-Number-Low Patients
por: Stögbauer, Fabian, et al.
Publicado: (2023)

A Pair of Prognostic Biomarkers in Triple-Negative Breast Cancer: KLK10 and KLK11 mRNA Expression
por: Liu, Yueyang, et al.
Publicado: (2022)

Platelet mitochondrial membrane depolarization reflects disease severity in patients with preeclampsia
por: Kraemer, Bjoern F., et al.
Publicado: (2022)

Modulation of CXCR3 ligand secretion by prostaglandin E(2 )and cyclooxygenase inhibitors in human breast cancer
por: Bronger, Holger, et al.
Publicado: (2012)

Clinical performance of an analytically validated assay in comparison to microarray technology to assess PITX2 DNA-methylation in breast cancer
por: Schricker, Gabriele, et al.
Publicado: (2018)

The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations
por: Willvonseder, Barbara, et al.
Publicado: (2020)

Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients
por: Gong, Weiwei, et al.
Publicado: (2020)

First prospective outcome data for the second-generation multigene test Endopredict in ER-positive/HER2-negative breast cancer
por: Ettl, Johannes, et al.
Publicado: (2020)

Genetically Engineered Mouse Models of Liver Tumorigenesis Reveal a Wide Histological Spectrum of Neoplastic and Non-Neoplastic Liver Lesions
por: Steiger, Katja, et al.
Publicado: (2020)

Prognosis of ovarian cancer is associated with effector memory CD8(+) T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells
por: Lieber, Sonja, et al.
Publicado: (2018)

Perspective of α(v)β(6)-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions
por: Steiger, Katja, et al.
Publicado: (2017)

Correlation of in vivo imaging to morphomolecular pathology in translational research: challenge accepted
por: Ballke, Simone, et al.
Publicado: (2021)

The limits of molecular signatures for pancreatic ductal adenocarcinoma subtyping
por: Lautizi, Manuela, et al.
Publicado: (2022)

Tracking a TGF-β activator in vivo: sensitive PET imaging of αvβ8-integrin with the Ga-68-labeled cyclic RGD octapeptide trimer Ga-68-Triveoctin
por: Quigley, Neil Gerard, et al.
Publicado: (2020)

Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer
por: Gong, Weiwei, et al.
Publicado: (2019)

Increased intraepithelial CD3+ T-lymphocytes and high PD-L1 expression on tumor cells are associated with a favorable prognosis in esophageal squamous cell carcinoma and allow prognostic immunogenic subgrouping
por: Jesinghaus, Moritz, et al.
Publicado: (2017)

Intracavitary brachytherapy with additional Heyman capsules in the treatment of cervical cancer
por: Scharl, Sophia, et al.
Publicado: (2022)

CD274/PD-L1 gene amplification and PD-L1 protein expression are common events in squamous cell carcinoma of the oral cavity
por: Straub, Melanie, et al.
Publicado: (2016)

Emerging clinical importance of the cancer biomarkers kallikrein-related peptidases (KLK) in female and male reproductive organ malignancies
por: Schmitt, Manfred, et al.
Publicado: (2013)

Introducing a novel highly prognostic grading scheme based on tumour budding and cell nest size for squamous cell carcinoma of the uterine cervix
por: Jesinghaus, Moritz, et al.
Publicado: (2018)

OVSCORE - a validated score to identify ovarian cancer patients not suitable for primary surgery
por: DORN, JULIA, et al.
Publicado: (2015)

Downregulation of Serine Protease HTRA1 Is Associated with Poor Survival in Breast Cancer
por: Lehner, Anna, et al.
Publicado: (2013)

Vascular Remodeling Is a Crucial Event in the Early Phase of Hepatocarcinogenesis in Rodent Models for Liver Tumorigenesis
por: Tulessin, Margaret, et al.
Publicado: (2022)

Immunology and Immune Checkpoint Inhibition in Ovarian Cancer – Current Aspects
por: Bronger, Holger
Publicado: (2021)

Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma
por: Candido, Juliana B., et al.
Publicado: (2021)

CXCL5 drives obesity to diabetes, and further
por: Chavey, Carine, et al.
Publicado: (2009)

PITX2 DNA-methylation predicts response to anthracycline-based adjuvant chemotherapy in triple-negative breast cancer patients
por: Absmaier, Magdalena, et al.
Publicado: (2018)

The Predictive Value of PITX2 DNA Methylation for High-Risk Breast Cancer Therapy: Current Guidelines, Medical Needs, and Challenges
por: Aubele, Michaela, et al.
Publicado: (2017)

CXCL5: A coachman to drive cancer progression
por: Deng, Jie, et al.
Publicado: (2022)

CX3CL1 Overexpression Prevents the Formation of Lung Metastases in Trastuzumab-Treated MDA-MB-453-Based Humanized Tumor Mice (HTM)
por: Wege, Anja Kathrin, et al.
Publicado: (2021)

Correction to: In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography
por: Notni, Johannes, et al.
Publicado: (2019)

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography
por: Notni, Johannes, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ofq7ct9qeb944e8tjlp9h8qmff