A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells

The recent derivation of human trophoblast stem cells (hTSCs) provides a scalable in vitro model system of human placental development, but the molecular regulators of hTSC identity have not been systematically explored thus far. Here, we utilize a genome-wide CRISPR-Cas9 knockout screen to comprehe...

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Detalles Bibliográficos
Autores principales: Dong, Chen, Fu, Shuhua, Karvas, Rowan M., Chew, Brian, Fischer, Laura A., Xing, Xiaoyun, Harrison, Jessica K., Popli, Pooja, Kommagani, Ramakrishna, Wang, Ting, Zhang, Bo, Theunissen, Thorold W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090837/
https://www.ncbi.nlm.nih.gov/pubmed/35538076
http://dx.doi.org/10.1038/s41467-022-30207-9

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