Cargando…

Development of Low-Molecular-Weight Allosteric Agonist of Thyroid-Stimulating Hormone Receptor with Thyroidogenic Activity

To normalize the thyroid status in hypothyroidism caused by resistance to thyroid-stimulating hormone (TSH), low-molecular-weight allosteric agonists of TSH receptor can be used. A new compound ethyl-2-(4-(4-(5-amino-6-(tert-butylcarbamoyl)-2-(methylthio)thieno[2,3-d]-pyrimidine-4-yl)phenyl)-1H-1,2,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bakhtyukov, A. A., Derkach, K. V., Fokina, E. A., Sorokoumov, V. N., Zakharova, I. O., Bayunova, L. V., Shpakov, A. O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pleiades Publishing 2022
Materias:	Biochemistry, Biophysics, and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090882/ https://www.ncbi.nlm.nih.gov/pubmed/35538280 http://dx.doi.org/10.1134/S1607672922020016

Ejemplares similares

The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis
por: Bakhtyukov, Andrey A., et al.
Publicado: (2021)

Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats
por: Bakhtyukov, Andrey A., et al.
Publicado: (2020)

The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect
por: Derkach, Kira, et al.
Publicado: (2019)

Optimization of an in vitro assay methodology for competitive binding of thyroidogenic xenobiotics with thyroxine on human transthyretin and albumin
por: Hill, Katie L., et al.
Publicado: (2017)

Identification of allosteric disulfides from labile bonds in X-ray structures
por: Pijning, Aster E., et al.
Publicado: (2018)

Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan
por: Chepanova, A. A., et al.
Publicado: (2023)

Segregated water observed in a putative fish embryo cryopreservative
por: Kirichek, O., et al.
Publicado: (2016)

Dual PTP1B/TC-PTP Inhibitors: Biological Evaluation of 3-(Hydroxymethyl)cinnoline-4(1H)-Ones
por: Derkach, Kira V., et al.
Publicado: (2023)

Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance
por: Lai, Alex L., et al.
Publicado: (2017)

Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides
por: DeBerg, Hannah A., et al.
Publicado: (2016)

Label-free sensitive detection of influenza virus using PZT discs with a synthetic sialylglycopolymer receptor layer
por: Erofeev, Alexander S., et al.
Publicado: (2019)

The Variable CTCF Site from Drosophila melanogaster Ubx Gene is Redundant and Has no Insulator Activity
por: Ibragimov, A. N., et al.
Publicado: (2022)

Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia
por: Artemieva, K. A., et al.
Publicado: (2022)

Properties and Activity of Peptide Derivatives of ACE2 Cellular Receptor and Their Interaction with SARS-CoV-2 S Protein Receptor-Binding Domain
por: Sidorova, M. V., et al.
Publicado: (2022)

Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
por: Rykunova, E. B., et al.
Publicado: (2023)

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION
por: Mould, A. Paul, et al.
Publicado: (2016)

Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancy
por: Kalinin, R. S., et al.
Publicado: (2023)

Differences in Presentation of SARS-CoV-2 Omicron Strain Variant BA.1–BA.5 Peptides by HLA Molecules
por: Nersisyan, S. A., et al.
Publicado: (2023)

Production of a Cloned Offspring and CRISPR/Cas9 Genome Editing of Embryonic Fibroblasts in Cattle
por: Singina, G. N., et al.
Publicado: (2021)

Immortalization of Human Keratinocytes Using the Catalytic Subunit of Telomerase
por: Beilin, A. K., et al.
Publicado: (2021)

Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators
por: Kyrchanova, O. V., et al.
Publicado: (2022)

Synthesis and Anti-influenza Activity of Vinylphosphonic Acid (Co)polymers
por: Zarubaev, V. V., et al.
Publicado: (2022)

Effect of Gamma Radiation on Cytogenetic and Growth Endpoints of Allium cepa Seedlings in Long-Term Experiments
por: Bolsunovsky, A. Ya., et al.
Publicado: (2022)

Novel Negative Sense Genes in the RNA Genome of Coronaviruses
por: Zhirnov, O. P., et al.
Publicado: (2021)

Synthesis of Fluorine-Containing Analogues of Purine Deoxynucleosides: Optimization of Enzymatic Transglycosylation Conditions
por: Drenichev, M. S., et al.
Publicado: (2022)

Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface
por: Ivanova, O. K., et al.
Publicado: (2023)

Phospholipids, cerebroside, and cerebroside sulfate levels in the CNS of mice withacute experimental viral demyelination
por: Annanepesov, Kh. N., et al.
Publicado: (1985)

Upconversion Nanoparticles Decorated with Polysialic Acid for Solid Tumors Visualization In Vivo
por: Demina, P. A., et al.
Publicado: (2021)

Transcription Factors of the GLRs Family Are Involved in Cytokinin-Dependent Regulation of Plastid RNA Polymerase SCA3 Gene Expression during Deetiolation of Arabidopsis thaliana
por: Doroshenko, A. S., et al.
Publicado: (2022)

The Recombinant Luciferase of the Fungus Neonothopanus nambi: Obtaining and Properties
por: Gorokhovatsky, A. Yu., et al.
Publicado: (2021)

Hypothesized diprotomeric enzyme complex supported by stochastic modelling of palytoxin-induced Na/K pump channels
por: Vilallonga, Gabriel D., et al.
Publicado: (2018)

Thermovaccination: Thermoheliox as an Immune Response Stimulant. Kinetics of Antibodies and C-Reactive Protein Synthesis in Coronaviral Infection
por: Varfolomeev, S. D., et al.
Publicado: (2021)

Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism
por: Li, Yang, et al.
Publicado: (2017)

Influence of a Constant Magnetic Field on the Infectious Titer of Black Sea Algal Viruses
por: Stepanova, O. A., et al.
Publicado: (2022)

Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells
por: Ivanova, O. K., et al.
Publicado: (2022)

Association of HLA Class I Genotype with Mortality in Patients with Diabetes Mellitus and COVID-19
por: Shkurnikov, M. Yu., et al.
Publicado: (2023)

Among Antibody-Like Molecules, Monobodies, Able to Interact with Nucleocapsid Protein of SARS-CoV Virus, There Are Monobodies with High Affinity to Nucleocapsid Protein of SARS-CoV-2 Virus
por: Khramtsov, Y. V., et al.
Publicado: (2022)

Delivery of Antibody-Like Molecules, Monobodies, Capable of Binding with SARS-CoV-2 Virus Nucleocapsid Protein, into Target Cells
por: Khramtsov, Y. V., et al.
Publicado: (2022)

GSK3 Kinase Inhibitor, CHIR, Suppress Transcription of Tissue Specific POU2F1 Isoform in Burkitt Namalwa Lymphoma Cells
por: Pankratova, E. V., et al.
Publicado: (2021)

5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt’s Lymphoma Cell Culture
por: Kotnova, A. P., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fgb5f9h4lujtja8i0823f1fp77