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The Prognostic Significance of Spliceosomal Proteins for Patients with Glioblastoma

Glioblastoma (GBM) is considered one of the most aggressive human cancers. Earlier, our group have demonstrated that alternative RNA splicing plays an important role in the regulation of the GBM phenotype. To continue this study, we analyzed the type of RNA splicing and the expression levels of the...

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Autores principales: Larionova, T. D., Kovalenko, T. F., Shakhparonov, M. I., Pavlyukov, M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090887/
https://www.ncbi.nlm.nih.gov/pubmed/35538281
http://dx.doi.org/10.1134/S1607672922020090
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author Larionova, T. D.
Kovalenko, T. F.
Shakhparonov, M. I.
Pavlyukov, M. S.
author_facet Larionova, T. D.
Kovalenko, T. F.
Shakhparonov, M. I.
Pavlyukov, M. S.
author_sort Larionova, T. D.
collection PubMed
description Glioblastoma (GBM) is considered one of the most aggressive human cancers. Earlier, our group have demonstrated that alternative RNA splicing plays an important role in the regulation of the GBM phenotype. To continue this study, we analyzed the type of RNA splicing and the expression levels of the spliceosomal genes in a large number of tumor tissue samples and patient-derived GBM sphere lines. We demonstrated that the expression level of splicing factors allows dividing GBM patients into groups with different survival prognosis and also reflects the phenotype of the tumor. In addition, we identified the alternative splicing events that may regulate the GBM phenotype. Finally, we for the first time compared the expression profiles of the spliceosomal genes in different regions of the same tumor and identified splicing factors whose expression most significantly correlates with GBM patients’ survival. Aforementioned data emphasize the important role of pre-mRNA splicing in GBM progression.
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spelling pubmed-90908872022-05-12 The Prognostic Significance of Spliceosomal Proteins for Patients with Glioblastoma Larionova, T. D. Kovalenko, T. F. Shakhparonov, M. I. Pavlyukov, M. S. Dokl Biochem Biophys Biochemistry, Biophysics, and Molecular Biology Glioblastoma (GBM) is considered one of the most aggressive human cancers. Earlier, our group have demonstrated that alternative RNA splicing plays an important role in the regulation of the GBM phenotype. To continue this study, we analyzed the type of RNA splicing and the expression levels of the spliceosomal genes in a large number of tumor tissue samples and patient-derived GBM sphere lines. We demonstrated that the expression level of splicing factors allows dividing GBM patients into groups with different survival prognosis and also reflects the phenotype of the tumor. In addition, we identified the alternative splicing events that may regulate the GBM phenotype. Finally, we for the first time compared the expression profiles of the spliceosomal genes in different regions of the same tumor and identified splicing factors whose expression most significantly correlates with GBM patients’ survival. Aforementioned data emphasize the important role of pre-mRNA splicing in GBM progression. Pleiades Publishing 2022-05-10 2022 /pmc/articles/PMC9090887/ /pubmed/35538281 http://dx.doi.org/10.1134/S1607672922020090 Text en © The Author(s) 2022, ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022, Vol. 503, pp. 71–75. © The Author(s), 2022. This article is an open access publication.Russian Text © The Author(s), 2022, published in Doklady Rossiiskoi Akademii Nauk. Nauki o Zhizni, 2022, Vol. 503, pp. 166–171. https://creativecommons.org/licenses/by/4.0/Open Access.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biochemistry, Biophysics, and Molecular Biology
Larionova, T. D.
Kovalenko, T. F.
Shakhparonov, M. I.
Pavlyukov, M. S.
The Prognostic Significance of Spliceosomal Proteins for Patients with Glioblastoma
title The Prognostic Significance of Spliceosomal Proteins for Patients with Glioblastoma
title_full The Prognostic Significance of Spliceosomal Proteins for Patients with Glioblastoma
title_fullStr The Prognostic Significance of Spliceosomal Proteins for Patients with Glioblastoma
title_full_unstemmed The Prognostic Significance of Spliceosomal Proteins for Patients with Glioblastoma
title_short The Prognostic Significance of Spliceosomal Proteins for Patients with Glioblastoma
title_sort prognostic significance of spliceosomal proteins for patients with glioblastoma
topic Biochemistry, Biophysics, and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090887/
https://www.ncbi.nlm.nih.gov/pubmed/35538281
http://dx.doi.org/10.1134/S1607672922020090
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