Statin therapy inhibits fatty acid synthase via dynamic protein modifications

Statins are a class of drug widely prescribed for the prevention of cardiovascular disease, with pleiotropic cellular effects. Statins inhibit HMG-CoA reductase (HMGCR), which converts the metabolite HMG-CoA into mevalonate. Recent discoveries have shown HMG-CoA is a reactive metabolite that can non...

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Detalles Bibliográficos
Autores principales: Trub, Alec G., Wagner, Gregory R., Anderson, Kristin A., Crown, Scott B., Zhang, Guo-Fang, Thompson, J. Will, Ilkayeva, Olga R., Stevens, Robert D., Grimsrud, Paul A., Kulkarni, Rhushikesh A., Backos, Donald S., Meier, Jordan L., Hirschey, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090928/
https://www.ncbi.nlm.nih.gov/pubmed/35538051
http://dx.doi.org/10.1038/s41467-022-30060-w

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