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No apparent association between mRNA COVID-19 vaccination and venous thromboembolism

By January 2022 over ten billion doses of COVID-19 vaccines had been administered worldwide. Concerns about COVID-19 vaccine-associated thrombosis arose after the characterization of a rare prothrombotic condition associated with adenoviral vector-based COVID-19 vaccines known as vaccine-induced imm...

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Autores principales: Nicholson, Matthew, Goubran, Hadi, Chan, Noel, Siegal, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091073/
https://www.ncbi.nlm.nih.gov/pubmed/35577626
http://dx.doi.org/10.1016/j.blre.2022.100970
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author Nicholson, Matthew
Goubran, Hadi
Chan, Noel
Siegal, Deborah
author_facet Nicholson, Matthew
Goubran, Hadi
Chan, Noel
Siegal, Deborah
author_sort Nicholson, Matthew
collection PubMed
description By January 2022 over ten billion doses of COVID-19 vaccines had been administered worldwide. Concerns about COVID-19 vaccine-associated thrombosis arose after the characterization of a rare prothrombotic condition associated with adenoviral vector-based COVID-19 vaccines known as vaccine-induced immune thrombotic thrombocytopenia (VITT). Although mRNA COVID-19 vaccines have not been linked to VITT, concerns about thrombosis after vaccination persist despite safety data from hundreds of millions of recipients of mRNA COVID-19 vaccines. With widespread vaccination some VTE will occur shortly after vaccination by chance alone because VTE is a common condition that affects 1 to 2 in 1000 persons each year. Detailed analysis is required to determine whether these VTE events are coincidental or associated when they occur in close proximity to mRNA vaccine administration. This paper will review what is currently known about rates of VTE after mRNA vaccination in adults, discuss the reasons why uncertainty on this topic persists, and briefly review the implications of these findings for clinical practice and health policy.
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spelling pubmed-90910732022-05-11 No apparent association between mRNA COVID-19 vaccination and venous thromboembolism Nicholson, Matthew Goubran, Hadi Chan, Noel Siegal, Deborah Blood Rev Review By January 2022 over ten billion doses of COVID-19 vaccines had been administered worldwide. Concerns about COVID-19 vaccine-associated thrombosis arose after the characterization of a rare prothrombotic condition associated with adenoviral vector-based COVID-19 vaccines known as vaccine-induced immune thrombotic thrombocytopenia (VITT). Although mRNA COVID-19 vaccines have not been linked to VITT, concerns about thrombosis after vaccination persist despite safety data from hundreds of millions of recipients of mRNA COVID-19 vaccines. With widespread vaccination some VTE will occur shortly after vaccination by chance alone because VTE is a common condition that affects 1 to 2 in 1000 persons each year. Detailed analysis is required to determine whether these VTE events are coincidental or associated when they occur in close proximity to mRNA vaccine administration. This paper will review what is currently known about rates of VTE after mRNA vaccination in adults, discuss the reasons why uncertainty on this topic persists, and briefly review the implications of these findings for clinical practice and health policy. The Authors. Published by Elsevier Ltd. 2022-11 2022-05-11 /pmc/articles/PMC9091073/ /pubmed/35577626 http://dx.doi.org/10.1016/j.blre.2022.100970 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Nicholson, Matthew
Goubran, Hadi
Chan, Noel
Siegal, Deborah
No apparent association between mRNA COVID-19 vaccination and venous thromboembolism
title No apparent association between mRNA COVID-19 vaccination and venous thromboembolism
title_full No apparent association between mRNA COVID-19 vaccination and venous thromboembolism
title_fullStr No apparent association between mRNA COVID-19 vaccination and venous thromboembolism
title_full_unstemmed No apparent association between mRNA COVID-19 vaccination and venous thromboembolism
title_short No apparent association between mRNA COVID-19 vaccination and venous thromboembolism
title_sort no apparent association between mrna covid-19 vaccination and venous thromboembolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091073/
https://www.ncbi.nlm.nih.gov/pubmed/35577626
http://dx.doi.org/10.1016/j.blre.2022.100970
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