Cargando…

What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?

Medical use of cannabis has been receiving growing attention over the last few decades in modern medicine. As we know that the endocannabinoid system is largely involved in neurological disorders, we focused on the scientific rationale of medical cannabis in three neurological disorders: amyotrophic...

Descripción completa

Detalles Bibliográficos
Autores principales: Lacroix, Clémence, Alleman-Brimault, Isabelle, Zalta, Arnaud, Rouby, Frank, Cassé-Perrot, Catherine, Jouve, Elisabeth, Attolini, Laurence, Guilhaumou, Romain, Micallef, Joëlle, Blin, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091192/
https://www.ncbi.nlm.nih.gov/pubmed/35571129
http://dx.doi.org/10.3389/fphar.2022.883987
_version_ 1784704867146661888
author Lacroix, Clémence
Alleman-Brimault, Isabelle
Zalta, Arnaud
Rouby, Frank
Cassé-Perrot, Catherine
Jouve, Elisabeth
Attolini, Laurence
Guilhaumou, Romain
Micallef, Joëlle
Blin, Olivier
author_facet Lacroix, Clémence
Alleman-Brimault, Isabelle
Zalta, Arnaud
Rouby, Frank
Cassé-Perrot, Catherine
Jouve, Elisabeth
Attolini, Laurence
Guilhaumou, Romain
Micallef, Joëlle
Blin, Olivier
author_sort Lacroix, Clémence
collection PubMed
description Medical use of cannabis has been receiving growing attention over the last few decades in modern medicine. As we know that the endocannabinoid system is largely involved in neurological disorders, we focused on the scientific rationale of medical cannabis in three neurological disorders: amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease through pharmacological plausibility, clinical studies, and patients’ view. Clinical studies (randomized controlled trials, open-label studies, cohorts, and case reports) exploring medical cannabis in these disorders show different results depending on the methods and outcomes. Some show benefits on motor symptoms and others on non-motor symptoms and quality of life. Concerning patients’ view, several web surveys were collected, highlighting the real use of cannabis to relieve symptoms of neurological disorders, mostly outside a medical pathway. This anarchic use keeps questioning particularly in terms of risks: consumption of street cannabis, drug–drug interactions with usual medical treatment, consideration of medical history, and adverse reactions (psychiatric, respiratory, cardiovascular disorders, etc.), underlining the importance of a medical supervision. To date, most scientific data support the therapeutic potential of cannabis in neurological disorders. As far as patients and patients’ associations are calling for it, there is an urgent need to manage clinical studies to provide stronger evidence and secure medical cannabis use.
format Online
Article
Text
id pubmed-9091192
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90911922022-05-12 What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps? Lacroix, Clémence Alleman-Brimault, Isabelle Zalta, Arnaud Rouby, Frank Cassé-Perrot, Catherine Jouve, Elisabeth Attolini, Laurence Guilhaumou, Romain Micallef, Joëlle Blin, Olivier Front Pharmacol Pharmacology Medical use of cannabis has been receiving growing attention over the last few decades in modern medicine. As we know that the endocannabinoid system is largely involved in neurological disorders, we focused on the scientific rationale of medical cannabis in three neurological disorders: amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease through pharmacological plausibility, clinical studies, and patients’ view. Clinical studies (randomized controlled trials, open-label studies, cohorts, and case reports) exploring medical cannabis in these disorders show different results depending on the methods and outcomes. Some show benefits on motor symptoms and others on non-motor symptoms and quality of life. Concerning patients’ view, several web surveys were collected, highlighting the real use of cannabis to relieve symptoms of neurological disorders, mostly outside a medical pathway. This anarchic use keeps questioning particularly in terms of risks: consumption of street cannabis, drug–drug interactions with usual medical treatment, consideration of medical history, and adverse reactions (psychiatric, respiratory, cardiovascular disorders, etc.), underlining the importance of a medical supervision. To date, most scientific data support the therapeutic potential of cannabis in neurological disorders. As far as patients and patients’ associations are calling for it, there is an urgent need to manage clinical studies to provide stronger evidence and secure medical cannabis use. Frontiers Media S.A. 2022-04-27 /pmc/articles/PMC9091192/ /pubmed/35571129 http://dx.doi.org/10.3389/fphar.2022.883987 Text en Copyright © 2022 Lacroix, Alleman-Brimault, Zalta, Rouby, Cassé-Perrot, Jouve, Attolini, Guilhaumou, Micallef and Blin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lacroix, Clémence
Alleman-Brimault, Isabelle
Zalta, Arnaud
Rouby, Frank
Cassé-Perrot, Catherine
Jouve, Elisabeth
Attolini, Laurence
Guilhaumou, Romain
Micallef, Joëlle
Blin, Olivier
What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?
title What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?
title_full What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?
title_fullStr What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?
title_full_unstemmed What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?
title_short What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?
title_sort what do we know about medical cannabis in neurological disorders and what are the next steps?
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091192/
https://www.ncbi.nlm.nih.gov/pubmed/35571129
http://dx.doi.org/10.3389/fphar.2022.883987
work_keys_str_mv AT lacroixclemence whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps
AT allemanbrimaultisabelle whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps
AT zaltaarnaud whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps
AT roubyfrank whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps
AT casseperrotcatherine whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps
AT jouveelisabeth whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps
AT attolinilaurence whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps
AT guilhaumouromain whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps
AT micallefjoelle whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps
AT blinolivier whatdoweknowaboutmedicalcannabisinneurologicaldisordersandwhatarethenextsteps