Mitochondrial damage and activation of the cytosolic DNA sensor cGAS–STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice

Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been suggested to contribute to the pathogenesis of cardiovascular diseases. However, w...

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Detalles Bibliográficos
Autores principales: Yan, Meiling, Li, Yun, Luo, Qingmao, Zeng, Wenru, Shao, Xiaoqi, Li, Lun, Wang, Qing, Wang, Dongwei, Zhang, Yue, Diao, Hongtao, Rong, Xianglu, Bai, Yunlong, Guo, Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091247/
https://www.ncbi.nlm.nih.gov/pubmed/35538059
http://dx.doi.org/10.1038/s41420-022-01046-w

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