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Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study

Major depressive disorder (MDD) is frequently associated with poor response to treatment. Common antidepressants target neurotransmission and neuronal plasticity, which require adequate energy supply. As imaging studies indicate disturbances in central energy metabolism, and caloric restriction impr...

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Autores principales: Stapel, Britta, Fraccarollo, Daniela, Westhoff-Bleck, Mechthild, Bauersachs, Johann, Lichtinghagen, Ralf, Jahn, Kirsten, Burkert, Alexandra, Buchholz, Vanessa, Bleich, Stefan, Frieling, Helge, Ding, Xiao-Qi, Kahl, Kai G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091273/
https://www.ncbi.nlm.nih.gov/pubmed/35538177
http://dx.doi.org/10.1038/s41598-022-11639-1
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author Stapel, Britta
Fraccarollo, Daniela
Westhoff-Bleck, Mechthild
Bauersachs, Johann
Lichtinghagen, Ralf
Jahn, Kirsten
Burkert, Alexandra
Buchholz, Vanessa
Bleich, Stefan
Frieling, Helge
Ding, Xiao-Qi
Kahl, Kai G.
author_facet Stapel, Britta
Fraccarollo, Daniela
Westhoff-Bleck, Mechthild
Bauersachs, Johann
Lichtinghagen, Ralf
Jahn, Kirsten
Burkert, Alexandra
Buchholz, Vanessa
Bleich, Stefan
Frieling, Helge
Ding, Xiao-Qi
Kahl, Kai G.
author_sort Stapel, Britta
collection PubMed
description Major depressive disorder (MDD) is frequently associated with poor response to treatment. Common antidepressants target neurotransmission and neuronal plasticity, which require adequate energy supply. As imaging studies indicate disturbances in central energy metabolism, and caloric restriction improves neuroplasticity and impacts mood and cognition, correction of energy status might increase the effectiveness of antidepressant treatments and reduce the psychopathological symptoms of depression. Metabolic parameters, stress hormones, and brain-derived neurotrophic factor (BDNF) levels were assessed in serum of depressed inpatients (MDD, N = 21) and healthy volunteers (Ctrl, N = 28) before and after a 72 h fasting period during which only water was consumed. Depression severity was assessed by Beck’s Depression Inventory (BDI)-2 sum-score and cognitive-affective and somatic sub-scores. Fasting similarly impacted metabolic parameters and stress systems in both groups. Fasting elevated BDI-2 sum-scores and somatic sub-scores in Ctrl. In MDD, fasting increased somatic-, but decreased cognitive-affective symptoms. Sub-group analyses based on BDI-2 sum-scores pre-fasting showed that cognitive-affective symptoms decreased in patients with moderate/severe but not in those with mild symptoms. This was associated with differential changes in BDNF levels. In conclusion, fasting improved cognitive-affective sub-scores in MDD patients with moderate/severe symptoms that had not responded to prior therapy. Interventions that modulate energy metabolism might directly improve cognitive-affective symptoms and/or augment therapeutic efficacy in moderate-to-severely depressed patients.
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spelling pubmed-90912732022-05-12 Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study Stapel, Britta Fraccarollo, Daniela Westhoff-Bleck, Mechthild Bauersachs, Johann Lichtinghagen, Ralf Jahn, Kirsten Burkert, Alexandra Buchholz, Vanessa Bleich, Stefan Frieling, Helge Ding, Xiao-Qi Kahl, Kai G. Sci Rep Article Major depressive disorder (MDD) is frequently associated with poor response to treatment. Common antidepressants target neurotransmission and neuronal plasticity, which require adequate energy supply. As imaging studies indicate disturbances in central energy metabolism, and caloric restriction improves neuroplasticity and impacts mood and cognition, correction of energy status might increase the effectiveness of antidepressant treatments and reduce the psychopathological symptoms of depression. Metabolic parameters, stress hormones, and brain-derived neurotrophic factor (BDNF) levels were assessed in serum of depressed inpatients (MDD, N = 21) and healthy volunteers (Ctrl, N = 28) before and after a 72 h fasting period during which only water was consumed. Depression severity was assessed by Beck’s Depression Inventory (BDI)-2 sum-score and cognitive-affective and somatic sub-scores. Fasting similarly impacted metabolic parameters and stress systems in both groups. Fasting elevated BDI-2 sum-scores and somatic sub-scores in Ctrl. In MDD, fasting increased somatic-, but decreased cognitive-affective symptoms. Sub-group analyses based on BDI-2 sum-scores pre-fasting showed that cognitive-affective symptoms decreased in patients with moderate/severe but not in those with mild symptoms. This was associated with differential changes in BDNF levels. In conclusion, fasting improved cognitive-affective sub-scores in MDD patients with moderate/severe symptoms that had not responded to prior therapy. Interventions that modulate energy metabolism might directly improve cognitive-affective symptoms and/or augment therapeutic efficacy in moderate-to-severely depressed patients. Nature Publishing Group UK 2022-05-10 /pmc/articles/PMC9091273/ /pubmed/35538177 http://dx.doi.org/10.1038/s41598-022-11639-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Stapel, Britta
Fraccarollo, Daniela
Westhoff-Bleck, Mechthild
Bauersachs, Johann
Lichtinghagen, Ralf
Jahn, Kirsten
Burkert, Alexandra
Buchholz, Vanessa
Bleich, Stefan
Frieling, Helge
Ding, Xiao-Qi
Kahl, Kai G.
Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study
title Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study
title_full Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study
title_fullStr Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study
title_full_unstemmed Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study
title_short Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study
title_sort impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091273/
https://www.ncbi.nlm.nih.gov/pubmed/35538177
http://dx.doi.org/10.1038/s41598-022-11639-1
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