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Allosteric inhibition induces an open WPD-loop: a new avenue towards glioblastoma therapy

The mobility of loops around the catalytic site of a protein remains crucial to its activity. Dynamics of the WPD-loop is an essential determinant of the catalytic activity of tyrosine-protein phosphatase zeta, an implicated protein in glioblastoma cells. The WPD-loop assumes a closed conformation u...

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Detalles Bibliográficos
Autores principales: Agoni, Clement, Ramharack, Pritika, Soliman, Mahmoud E. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091281/
https://www.ncbi.nlm.nih.gov/pubmed/35558220
http://dx.doi.org/10.1039/c8ra08427k

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