Cargando…
Control of the stereochemistry of C14 hydroxyl during the total synthesis of withanolide E and physachenolide C
The stereochemical outcome of the epoxidation of Δ(14–15) cholestanes with mCPBA is controlled by the steric bulk of a C17 substituent. When the C17 is in the β configuration, the epoxide is formed in the α face, whereas if the C17 is trigonal (flat) or the substituent is in the α configuration, the...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091292/ https://www.ncbi.nlm.nih.gov/pubmed/35558026 http://dx.doi.org/10.1039/c8ra08540d |