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Effect of double mutations T790M/L858R on conformation and drug-resistant mechanism of epidermal growth factor receptor explored by molecular dynamics simulations

Epidermal growth factor receptor (EGFR) is one of the most promising targets for the treatment of cancers. Double mutations T790M/L858R lead to different degrees of drug resistance toward inhibitors. In this study, molecular dynamics (MD) simulations followed by principal component analysis are perf...

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Detalles Bibliográficos
Autores principales:	Yan, Fangfang, Liu, Xinguo, Zhang, Shaolong, Su, Jing, Zhang, Qinggang, Chen, Jianzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091310/ https://www.ncbi.nlm.nih.gov/pubmed/35558225 http://dx.doi.org/10.1039/c8ra06844e

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