Applications of Friedel–Crafts reactions in total synthesis of natural products
Over the years, Friedel–Crafts (FC) reactions have been acknowledged as the most useful and powerful synthetic tools for the construction of a special kind of carbon–carbon bond involving an aromatic moiety. Its stoichiometric and, more recently, its catalytic procedures have extensively been studie...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091380/ https://www.ncbi.nlm.nih.gov/pubmed/35558228 http://dx.doi.org/10.1039/c8ra07325b |
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author | Heravi, Majid M. Zadsirjan, Vahideh Saedi, Pegah Momeni, Tayebeh |
author_facet | Heravi, Majid M. Zadsirjan, Vahideh Saedi, Pegah Momeni, Tayebeh |
author_sort | Heravi, Majid M. |
collection | PubMed |
description | Over the years, Friedel–Crafts (FC) reactions have been acknowledged as the most useful and powerful synthetic tools for the construction of a special kind of carbon–carbon bond involving an aromatic moiety. Its stoichiometric and, more recently, its catalytic procedures have extensively been studied. This reaction in recent years has frequently been used as a key step (steps) in the total synthesis of natural products and targeted complex bioactive molecules. In this review, we try to underscore the applications of intermolecular and intramolecular FC reactions in the total syntheses of natural products and complex molecules, exhibiting diverse biological properties. |
format | Online Article Text |
id | pubmed-9091380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90913802022-05-11 Applications of Friedel–Crafts reactions in total synthesis of natural products Heravi, Majid M. Zadsirjan, Vahideh Saedi, Pegah Momeni, Tayebeh RSC Adv Chemistry Over the years, Friedel–Crafts (FC) reactions have been acknowledged as the most useful and powerful synthetic tools for the construction of a special kind of carbon–carbon bond involving an aromatic moiety. Its stoichiometric and, more recently, its catalytic procedures have extensively been studied. This reaction in recent years has frequently been used as a key step (steps) in the total synthesis of natural products and targeted complex bioactive molecules. In this review, we try to underscore the applications of intermolecular and intramolecular FC reactions in the total syntheses of natural products and complex molecules, exhibiting diverse biological properties. The Royal Society of Chemistry 2018-12-03 /pmc/articles/PMC9091380/ /pubmed/35558228 http://dx.doi.org/10.1039/c8ra07325b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Heravi, Majid M. Zadsirjan, Vahideh Saedi, Pegah Momeni, Tayebeh Applications of Friedel–Crafts reactions in total synthesis of natural products |
title | Applications of Friedel–Crafts reactions in total synthesis of natural products |
title_full | Applications of Friedel–Crafts reactions in total synthesis of natural products |
title_fullStr | Applications of Friedel–Crafts reactions in total synthesis of natural products |
title_full_unstemmed | Applications of Friedel–Crafts reactions in total synthesis of natural products |
title_short | Applications of Friedel–Crafts reactions in total synthesis of natural products |
title_sort | applications of friedel–crafts reactions in total synthesis of natural products |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091380/ https://www.ncbi.nlm.nih.gov/pubmed/35558228 http://dx.doi.org/10.1039/c8ra07325b |
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