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Osteosclerotic Multiple Myeloma without POEMS Syndrome – A Rare Case Report

INTRODUCTION: Multiple myeloma is a plasma cell neoplasm that is commonly associated with lytic bone lesions; however, osteosclerotic multiple myeloma is a rare entity. Osteosclerotic multiple myeloma has been reported in association with POEMS syndrome. CASE PRESENTATION: A 60-year-old female patie...

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Autores principales: Divakar, M, Shyam, Ashok, Hadgaonkar, Shailesh, Sancheti, Parag, Aiyer, Siddharth N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Indian Orthopaedic Research Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091408/
https://www.ncbi.nlm.nih.gov/pubmed/35611283
http://dx.doi.org/10.13107/jocr.2022.v12.i01.2598
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author Divakar, M
Shyam, Ashok
Hadgaonkar, Shailesh
Sancheti, Parag
Aiyer, Siddharth N
author_facet Divakar, M
Shyam, Ashok
Hadgaonkar, Shailesh
Sancheti, Parag
Aiyer, Siddharth N
author_sort Divakar, M
collection PubMed
description INTRODUCTION: Multiple myeloma is a plasma cell neoplasm that is commonly associated with lytic bone lesions; however, osteosclerotic multiple myeloma is a rare entity. Osteosclerotic multiple myeloma has been reported in association with POEMS syndrome. CASE PRESENTATION: A 60-year-old female patient presented to us with low back pain for 2 months. The investigations revealed that the patient had multiple osteosclerotic lesions in the axial skeleton with a L4 ivory vertebra. The serum immunoelectrophoresis was negative. Positron emission tomography scan was done which showed multiple skeletal lesions in the right iliac bone, left femoral neck, thoracic vertebrae T1, T6, T12, and lumbar vertebra L4. Biopsy and immunohistochemistry of the lesion showed plasma cell proliferation; producing lambda light chains. However, there were no features of POEMS syndrome including polyneuropathy, organomegaly, endocrinopathy, and skin changes. The patient was started on chemoradiation and achieved clinical remission and was asymptomatic at 12 months follow-up. CONCLUSION: Osteosclerotic myeloma without the features of POEMS syndrome is an extremely rare entity. This case reports documents a unique clinical scenario of osteosclerotic non-secretory light chain myeloma without POEMS syndrome.
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spelling pubmed-90914082022-05-23 Osteosclerotic Multiple Myeloma without POEMS Syndrome – A Rare Case Report Divakar, M Shyam, Ashok Hadgaonkar, Shailesh Sancheti, Parag Aiyer, Siddharth N J Orthop Case Rep Case Report INTRODUCTION: Multiple myeloma is a plasma cell neoplasm that is commonly associated with lytic bone lesions; however, osteosclerotic multiple myeloma is a rare entity. Osteosclerotic multiple myeloma has been reported in association with POEMS syndrome. CASE PRESENTATION: A 60-year-old female patient presented to us with low back pain for 2 months. The investigations revealed that the patient had multiple osteosclerotic lesions in the axial skeleton with a L4 ivory vertebra. The serum immunoelectrophoresis was negative. Positron emission tomography scan was done which showed multiple skeletal lesions in the right iliac bone, left femoral neck, thoracic vertebrae T1, T6, T12, and lumbar vertebra L4. Biopsy and immunohistochemistry of the lesion showed plasma cell proliferation; producing lambda light chains. However, there were no features of POEMS syndrome including polyneuropathy, organomegaly, endocrinopathy, and skin changes. The patient was started on chemoradiation and achieved clinical remission and was asymptomatic at 12 months follow-up. CONCLUSION: Osteosclerotic myeloma without the features of POEMS syndrome is an extremely rare entity. This case reports documents a unique clinical scenario of osteosclerotic non-secretory light chain myeloma without POEMS syndrome. Indian Orthopaedic Research Group 2022-01 2022-01 /pmc/articles/PMC9091408/ /pubmed/35611283 http://dx.doi.org/10.13107/jocr.2022.v12.i01.2598 Text en Copyright: © Indian Orthopaedic Research Group https://creativecommons.org/licenses/by-nc-sa/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Divakar, M
Shyam, Ashok
Hadgaonkar, Shailesh
Sancheti, Parag
Aiyer, Siddharth N
Osteosclerotic Multiple Myeloma without POEMS Syndrome – A Rare Case Report
title Osteosclerotic Multiple Myeloma without POEMS Syndrome – A Rare Case Report
title_full Osteosclerotic Multiple Myeloma without POEMS Syndrome – A Rare Case Report
title_fullStr Osteosclerotic Multiple Myeloma without POEMS Syndrome – A Rare Case Report
title_full_unstemmed Osteosclerotic Multiple Myeloma without POEMS Syndrome – A Rare Case Report
title_short Osteosclerotic Multiple Myeloma without POEMS Syndrome – A Rare Case Report
title_sort osteosclerotic multiple myeloma without poems syndrome – a rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091408/
https://www.ncbi.nlm.nih.gov/pubmed/35611283
http://dx.doi.org/10.13107/jocr.2022.v12.i01.2598
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