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The Age-Adjusted Charlson Comorbidity Index Predicts Prognosis in Elderly Cancer Patients

PURPOSE: The age-adjusted Charlson comorbidity index (ACCI) is a useful measure of comorbidity to standardize the evaluation of elderly patients and has been reported to predict mortality in various cancers. To our best knowledge, no studies have examined the relationship between the ACCI and surviv...

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Autores principales: Zhou, Shi, Zhang, Xing-Hu, Zhang, Yuan, Gong, Ge, Yang, Xiang, Wan, Wen-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091471/
https://www.ncbi.nlm.nih.gov/pubmed/35573259
http://dx.doi.org/10.2147/CMAR.S361495
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author Zhou, Shi
Zhang, Xing-Hu
Zhang, Yuan
Gong, Ge
Yang, Xiang
Wan, Wen-Hui
author_facet Zhou, Shi
Zhang, Xing-Hu
Zhang, Yuan
Gong, Ge
Yang, Xiang
Wan, Wen-Hui
author_sort Zhou, Shi
collection PubMed
description PURPOSE: The age-adjusted Charlson comorbidity index (ACCI) is a useful measure of comorbidity to standardize the evaluation of elderly patients and has been reported to predict mortality in various cancers. To our best knowledge, no studies have examined the relationship between the ACCI and survival of elderly patients with cancer. Therefore, the primary objective of this study was to investigate the relationship between the ACCI and survival of elderly patients with cancer. PATIENTS AND METHODS: A total of 64 elderly patients (>80 years) with cancer between 2011 and 2021 were enrolled in this study. According to the ACCI, the age-adjusted comorbidity index was calculated by weighting individual comorbidities; patients with ACCI<11 were considered the low-ACCI group, whereas those with ACCI≥11 were considered the high-ACCI group. The correlations between the ACCI score and survival outcomes were statistically analyzed. RESULTS: There was a significant difference in overall survival (OS) and progression-free survival (PFS) between the high-ACCI group and the low-ACCI group (P<0.001). The median OS time of the high-ACCI group and the low-ACCI group were 13.9 (10.5–22.0) months and 51.9 (34.1–84.0) months, respectively. The 2-, 3-, and 5-year survival rates of the high-ACCI group were 28.1%, 18.8%, and 4.2%, respectively, whereas the 2-, 3-, and 5-year survival rates of the low-ACCI group were 77.3%, 66.4%, and 39.1%, respectively. Multivariate analysis showed that ACCI was independently associated with OS (HR=1.402, 95% CI: 1.226–1.604, P < 0.05) and PFS (HR=1.353, 95% CI: 1.085–1.688, P = 0.0073). CONCLUSION: The ACCI score is a significant independent predictor of prognosis in elderly patients with cancer.
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spelling pubmed-90914712022-05-12 The Age-Adjusted Charlson Comorbidity Index Predicts Prognosis in Elderly Cancer Patients Zhou, Shi Zhang, Xing-Hu Zhang, Yuan Gong, Ge Yang, Xiang Wan, Wen-Hui Cancer Manag Res Original Research PURPOSE: The age-adjusted Charlson comorbidity index (ACCI) is a useful measure of comorbidity to standardize the evaluation of elderly patients and has been reported to predict mortality in various cancers. To our best knowledge, no studies have examined the relationship between the ACCI and survival of elderly patients with cancer. Therefore, the primary objective of this study was to investigate the relationship between the ACCI and survival of elderly patients with cancer. PATIENTS AND METHODS: A total of 64 elderly patients (>80 years) with cancer between 2011 and 2021 were enrolled in this study. According to the ACCI, the age-adjusted comorbidity index was calculated by weighting individual comorbidities; patients with ACCI<11 were considered the low-ACCI group, whereas those with ACCI≥11 were considered the high-ACCI group. The correlations between the ACCI score and survival outcomes were statistically analyzed. RESULTS: There was a significant difference in overall survival (OS) and progression-free survival (PFS) between the high-ACCI group and the low-ACCI group (P<0.001). The median OS time of the high-ACCI group and the low-ACCI group were 13.9 (10.5–22.0) months and 51.9 (34.1–84.0) months, respectively. The 2-, 3-, and 5-year survival rates of the high-ACCI group were 28.1%, 18.8%, and 4.2%, respectively, whereas the 2-, 3-, and 5-year survival rates of the low-ACCI group were 77.3%, 66.4%, and 39.1%, respectively. Multivariate analysis showed that ACCI was independently associated with OS (HR=1.402, 95% CI: 1.226–1.604, P < 0.05) and PFS (HR=1.353, 95% CI: 1.085–1.688, P = 0.0073). CONCLUSION: The ACCI score is a significant independent predictor of prognosis in elderly patients with cancer. Dove 2022-05-06 /pmc/articles/PMC9091471/ /pubmed/35573259 http://dx.doi.org/10.2147/CMAR.S361495 Text en © 2022 Zhou et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhou, Shi
Zhang, Xing-Hu
Zhang, Yuan
Gong, Ge
Yang, Xiang
Wan, Wen-Hui
The Age-Adjusted Charlson Comorbidity Index Predicts Prognosis in Elderly Cancer Patients
title The Age-Adjusted Charlson Comorbidity Index Predicts Prognosis in Elderly Cancer Patients
title_full The Age-Adjusted Charlson Comorbidity Index Predicts Prognosis in Elderly Cancer Patients
title_fullStr The Age-Adjusted Charlson Comorbidity Index Predicts Prognosis in Elderly Cancer Patients
title_full_unstemmed The Age-Adjusted Charlson Comorbidity Index Predicts Prognosis in Elderly Cancer Patients
title_short The Age-Adjusted Charlson Comorbidity Index Predicts Prognosis in Elderly Cancer Patients
title_sort age-adjusted charlson comorbidity index predicts prognosis in elderly cancer patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091471/
https://www.ncbi.nlm.nih.gov/pubmed/35573259
http://dx.doi.org/10.2147/CMAR.S361495
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